Irina Matei, Weill Cornell Medicine, United States
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Will be Updated Soon...
Nano magnetite copper (I) complexes are exceptionally antibacterial, anticancer, anti-inflammatory, and antimicrobial capabilities, which have drawn particular attention as a potential class of medicinal medicines. Nano-magnetic copper complexes [Nano-magnetite-Lys@Cu(PPh3)I] and [....] » Read More
High-risk human papillomavirus (HR-HPV) infections are responsible for 7.7% of cancers in developing countries, mainly cervical cancer. Several studies reveal the presence of numerous oncogenic HR-HPV genotypes worldwide, but the presence and distribution of these genotypes remai [....] » Read More
Cancers that initially respond to chemotherapy may develop resistance, leading to unexpected tumor growth. This phenomenon, known as chemotherapy resistance, renders the treatment ineffective in eradicating cancer cells. This situation is profoundly disheartening for everyone inv [....] » Read More
According to the Barcelona Clinic Liver Cancer (BCLC) staging system, only the advanced stage (stage C) hepatocellular carcinoma (HCC) patient is eligible for systemic treatments. In addition to tyrosine kinase inhibitors, multikinase inhibitors and anti-vascular-endothelial gr [....] » Read More
Follicular dendritic cell sarcoma (FDCS) is a rare type of sarcoma that originates from the stromal component of the germinal center of the B-follicle. Its presentation and prognosis vary, as it can be nodal or extranodal, localized or multifocal, and can be fatal in 20% of cases [....] » Read More
Epithelial ovarian cancer (EOC) is the 5th cancer-related cause of death among women worldwide. EOC is usually diagnosed at an advanced stage when tumour cells have already spread throughout the pelvis in the peritoneal cavity. Five-year survival rate is around 30% in patients wi [....] » Read More
Chromatin bridges are strings of chromatin connecting the anaphase poles or daughter nuclei and have been linked to tumourigenesis. Chromatin bridges can arise from segregation of interlinked chromosomes after improper resolution of double strand DNA catenates, or from dicentric [....] » Read More
Herein, we would like to present the case of about 80-year-old female. Her chief complaint was bloody nipple discharge in the left breast. She came to our hospital for thorough examination and treatment. Ultrasonography detected intraductal carcinoma of about 10mm spreading. The [....] » Read More
Ovarian cancer is a complex disease associated with multiple genetic and epigenetic alterations. The emergence of treatment resistance in most patients causes ovarian cancer to become incurable, and novel therapies remain necessary. We identified epigenetic regulator ATPase famil [....] » Read More
Introduction & objectives: For localised tumours of the fifteen most lethal cancers globally, we aimed to compare both biopsy recommendations from leading guidelines and biopsy outcomes. Materials and methods: The most lethal fifteen malignancies globally were determi [....] » Read More
Colorectal cancer is globally one of the most prevalent cancers and a common cause of cancer-related mortality. The curative treatment is surgery. Unfortunately, recurrence is common with approximately 25% of the patients having relapse. Lymph node (LN) metastasis is the single m [....] » Read More
We present three cases of benign pediatric tumors in which there was significant diagnostic dilemma. We share our experience how a pre-sacral dermoid cyst gave rise to bowel bladder obstruction and subsequent incontinence, a retroperitoneum teratoma just superior to left kidney m [....] » Read More
Gastrointestinal metastases of lung cancer are relatively uncommon, yet occur at a higher frequency than would be expected among patients that exhibit a longer survival interval. Metastases that arise in the small intestines are often associated with no or few symptoms such that [....] » Read More
Introduction: Lubumbashi is the 2nd city in the DRC, 2,812,000 inhabitants (2023). Its pediatric oncology unit (CUL) works in collaboration with ophthalmologists, pathologists, surgeons, imagers, etc…(RCP). Financially supported by several NGOs including AMCC, GFAOP&h [....] » Read More
Chemotherapy, which is one of the gold standard management for cancer, brings with it a diverse range of side effects. Cancer has been described as a metabolic disease characterized by dysfunctional mitochondria and probably this is the reason why cancer cells shifts their metabo [....] » Read More
Introduction: Esophageal cancer is a challenging disease because it is aggressive and has limited treatment options. T-DM1, a medication targeting HER2-positive cancer cells, has shown promise in improving patient outcomes. However, drug resistance is still a significant obs [....] » Read More
We have developed a new noninvasive technique termed vibrational optical coherence tomography (VOCT) to optically image and measure the resonant frequency of cellular, blood vessel, papillary collagen, and fibrotic tissue in the skin. Preliminary results on normal skin indicate t [....] » Read More
Background: Placement of self-expandable metal stents (SEMS) by endoscopy has become a recommend treatment for esophagojejunal anastomotisis leakage (EJAL). There is no clear conclusion on whether neoadjuvant therapy will increase the incidence of EJAL in adenocarcinoma of the ga [....] » Read More
As the Coronavirus Disease 2019 (COVID-19) pandemic continues to pose a global health challenge, its impact on vulnerable populations, particularly those with lung neoplasms, has been profound. This systematic review aimed to delineate the range of COVID-19-related complications [....] » Read More
Title : Immunological interplay and therapeutic potential in severe SARS-CoV-2 infection among cancer patients: A model and intervention strategy
Yan Leyfman, Icahn School of Medicine, United States
Coronavirus disease 2019 (COVID-19), a respiratory illness caused by betacoronavirus SARS-CoV-2, has broad clinical presentations ranging from asymptomatic to fatal outcomes. Due to their immunocompromised status, cancer patients are at an increased risk for severe SARS-CoV-2 inf [....] » Read More
Title : Targeting oncogenic fusion genes in hepatocellular carcinoma
Jianhua Luo, University of Pittsburgh School of Medicine, United States
Hepatocellular carcinoma (HCC) is one of the most lethal cancers for humans. MAN2A1-FER is one of the most frequent oncogenic fusion genes in the HCC. In this report, we showed that MAN2A1-FER ectopically phosphorylated the extracellular domains of PDGFRA, MET, AXL, and N-cadheri [....] » Read More
Title : The construction of precision medicine in oncology : The example of sarcomas
Yves Marie Robin, Oscar Lambret Cancer Center, France
Precision medicine, in its quest for rapidly obtained, reliable, precise, accurate and informative druggable biotargets, prognostic markers or molecular signatures predictive of treatment outcome, is the driving momentum behind patient care nowadays in oncology. The two mod [....] » Read More
Title : Multiple endocrine neoplasia and sporadic insulinomas
Klaus Brusgaard, Odense University Hospital, Denmark
Functional pancreatic neuroendocrine tumors (PNETs) may be hereditary or sporadic. Hereditary forms are often caused by MEN1 mutations. The majority of insulinomas are sporadic, solitary and low-grade. The tumorigenesis in sporadic insulinomas is not well described. We describe t [....] » Read More
Title : Multiplexed detection of biomarkers for early-stage ovarian cancer
Michael Thompson, University of Toronto, Canada
Ovarian cancer (OC) results in some 150,000 deaths worldwide of nearly 300,000 new cases each year. Unfortunately, only 20 % of patients are diagnosed at the early stages (I and II) of the disease when treatment is most effective, leading to a 5- year relative survival rate of on [....] » Read More
Title : Towards a home companion diagnostic test for the early detection of breast cancer
Nur Aimi Aliah Zainurin, Aberystwyth University, United Kingdom
Breast cancer is one of the deadliest cancers with 685,000 deaths and 2.26 million cases reported in 2020. Early detection is crucial for better treatment outcome. Mammography is the gold standard screening modality for breast cancer diagnosis but use of a cost-effective companio [....] » Read More
Title : Metabolic health and lung cancer: Evidence from a prospective cohort study
Mengmeng Li, Sun Yat-Sen University Cancer Center, China
Background: Both the incidence of lung cancer and the prevalence of metabolic abnormalities, specifically metabolic syndrome (MetS), have been increasing worldwide. The relationship between MetS and lung cancer remains controversial. We aimed to investigate the association of Met [....] » Read More
Title : The role of hypoxic microenvironment in the progress of hepatoma carcinoma
Yufeng Wang, Xian Jiaotong University, China
Hypoxia is an inherent characteristic feature of the tumor microenvironment of hepatocellular carcinoma (HCC). Hypoxia inducible factors (HIFs), which are in charge of hundres of genes transcription at least, play essential roles in hypoxia-iinduced HCC progression. Increasing ev [....] » Read More
Title : Breast cancer identification and classification using data science and machine learning
Mane Davtyan, Information Systems Department, Armenia
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Title : Unveiling secrets and a permanent remedial approach for the global monster cancer
Surya Prakash Tadepalli, Founder President of the Jai Surya Multiple Knowledge Development Organization, India
Introduction: Up until recently, it was thought that cancer may strike without warning. Now, however, we know that each type of cancer has a specific cause, so let's see whether we can treat them all separately. We can now pinpoint the causes of every type of cancer as well a [....] » Read More
Title : NTF4 plays a dual role in breast cancer in mammary tumorigenesis and metastatic progression
Ran Sun, Chongqing Jiulongpo People’s Hospital, China
Breast cancer metastasis can happen even when the primary tumor is relatively small. But the mechanism for such early metastasis is poorly understood. Herein, we report that neurotrophin 4 (NTF4) plays a dual role in breast cancer proliferation and metastasis. Clinical data showe [....] » Read More
Title : Comprehensive molecular analyses of M2-Like tumor-associated macrophage for predicting the prognosis and immunotherapy in breast cancer
Zhang Yuan, Shannxi provincial People's hospital, China
The involvement of M2- like tumor assosiated macrophages TAM? in the advancement and treatment of cancers has been widely documented. The objectives of this study was to develop a new signature associated with M2- like TAMs to fore cast the prognosis and tratment response individ [....] » Read More
Title : ASPH inhibition reveals differential gene expression patterns in HPV-positive and HPV-negative cell lines.
Madiha Kanwal, BIOCEV, Charles University, Prague, Czech Republic
Cancer is associated with alterations in key cellular pathways, including the aspartate β-hydroxylase (ASPH) pathway. ASPH is an oncogene that is upregulated in various carcinomas and plays a vital role in tumor progression and metastasis. To better understand the mechanisms [....] » Read More