Asthma is a chronic condition of airways of lungs.
Asthma Immunopathology involves the activation of both the innate and adaptive immune systems to stimulate chronic airway inflammation.
Pathogenesis of asthma has changed dramatically. Whereas mast cells and eosinophils were initially believed to play a central role in driving the airway inflammation related to asthma. Asthma is regarded as an IgE-mediated sensitization to inhaled allergens with a Th2 cell response and subsequent eosinophilic inflammation. IgE and eosinophils play crucial roles within the pathogenesis of asthma. The Immune deviation toward a Th1 response can protect against asthma. Asthma associated with a Th2 sort of immune response.
Inflammatory profiles are largely determined by the involvement of various T helper cell subsets, which orchestrate the recruitment and activation of inflammatory cells. It is found that T helper cells other than Th2 cells are involved with in the pathogenesis of asthma; specifically, both Th1 and Th17 cells are for the development of neutrophilic inflammation with in the airways, which is a corticosteroid resistance.