Background. Haptoglobin is an acute-phase inflammatory protein mainly produced by the liver. Although recent literature evidence that rs2000999 in the HP gene is associated with total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels in Mexicans, little is known about the association between serum haptoglobin, obesity, and lipids in this population.
Objective. To analyze the association between serum haptoglobin, obesity, and lipids in 447 and 395 Mexican children and adults, respectively.
Methods. In this obesity case-control study, anthropometric data and serum lipids (TC, high-density lipoprotein cholesterol [HDL-C], LDL-C, and triglycerides [TG]) were analyzed. Haptoglobin was determined by immunoturbidimetry.
Results. Serum haptoglobin level was positively associated with childhood and adult obesity (Children: OR=1.014, 95% CI, 1.009-1.018, p=6.55x10-9; Adult: OR= 1.015, 95% CI, 1.010-1.021; P= 7.2 × 10-8). In children, a significant association was found between serum haptoglobin, TC (β= -0.068 ± 0.030, p= 0.023) and HDL-C (β= -0.031 ± 0.011, p= 0.004) levels. Additionally, significant interactions between obesity and serum haptoglobin level on LDL-C (β= -3.376±1.109, p=0.001), TC (β=-4.592±1.408, p=0.001), and TG (β=-9.318±2.600, p=0.001) were observed. In adults we did not find any significant association between serum haptoglobin level and lipids (p≥ 0.061).
Conclusion. Our results evidence a significant association between serum haptoglobin and childhood and adult obesity in Mexico. In addition, an obesity-specific association of serum haptoglobin with TC and LD levels was observed only in children.