Exercise induced muscle carbohydrate oxidation and its mechanisms are the panacea for overconsumption of carbohydrate. To my knowledge, muscle contraction is the only mechanism for Glut-4 protein translocation from within the cell to the cell surface for glucose uptake. Add [....] » Read More
Retinal photography was performed in pregnancy and postpartum in pregnant Hispanic women with latent Toxoplasma gondii (TG) infection (N=158) A comparison group of TG negative women (N=532) was included for data from the electronic health record (EHR).The goal & [....] » Read More
Type 2 diabetes mellitus (T2DM), characterized by hyperglycemia (≥126 mg glucose/100 ml blood after overnight fasting) and insulin resistance, is a major global health problem. Globally, approx. 6.7 million people died from diabetes in 2021, and total health expenditure due to [....] » Read More
Type 1 diabetes is an autoimmune disease characterized by attack from immune cells infiltrating the pancreas and loss of functional beta-cell mass, requiring exogenous insulin treatment. Novo Nordisk has conducted a randomized, double-blind, placebo-controlled, phase 2 trial asse [....] » Read More
Drug development is often challenged by the available human disease-relevant models that are available to understand targetable mechanisms and biomarkers of disease progression or response. Type 1 diabetes (T1D) is an autoimmune disease that leads to loss of beta cells and eventu [....] » Read More
The objectives of this research are to utilise competing risk methods in T2DM modeling by using patient data to subsequently evaluate which diabetic complication comes first. The analysis was performed using a simulation model of people with T2DM. The model simulated a cohort of [....] » Read More
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by high blood glucose levels resulting from defects in insulin secretion. A systemic review and meta analysis was conducted to determine effect of well known natural food supplements consumption on markers of gl [....] » Read More
Type-II diabetes is one of the most prevalent lifestyle diseases in the world, and the number of diabetic patients is rising quickly. It is crucial to consider how lifestyle factors like eating habits, exercise routines, stress levels, and others affect glucose-insulin dynamics a [....] » Read More
Background: Foot ulcers, especially dorsal foot ulcers caused by straps in footwear, can lead to discomfort, pain, and severe complications, particularly in individuals with diabetes and leprosy. While plantar foot pressure measurements have been extensively studied, research on [....] » Read More
Introduction: Our previous study demonstrated that adipocyte MTP regulates intracellular lipolysis by inhibiting ATGL activity. Adipose-specific MTP knockout mice (A-Mttp-/-) had smaller adipocytes and showed increased thermogenesis, and gained less weight on an obesogenic diet. [....] » Read More
There are 4.3 million people living in the UK with diabetes in 2023. In the USA there are 34 million with the disease. By 2025, it has been predicted that in the USA, the numbers will increase to 53.1 million with 72.9% or 38.7 million diagnosed and a further 27.1% or 14.4 millio [....] » Read More
Diabetes is a chronic illness that can occur in different periods of the person's life. The purpose of this study is to investigate the correlation of depression levels with HbA1c glycosylated hemoglobin values and gender, to determine the rate of depression in patients with [....] » Read More
Obesity is a growing epidemic in the world and impacts all functions of the body, including reproduction. An increase of consumption of diet containing fat or refined carbohydrate contributes to obesity and related diseases. Although studies have shown the obesity effect induced [....] » Read More
Type 1 diabetes (T1D) is associated with vascular complications that increase mortality risk, underpinned by extensive vascular disease coupled with an enhanced thrombotic environment. Previously, we investigated potential associations between fibrin clot properties and plasma ma [....] » Read More
High intake of refined carbohydrates with low consumption of dietary fibres (DFs), particularly from vegetables and has increased the risk of CVD, diabetes and other illnesses. The prevalence of chronic diseases is increasingly skyrocketing with the number of diabetic individuals [....] » Read More
The kidney's local Renin-Angiotensin System (RAS) plays a role in diabetic nephropathy (DN). Damage to the kidneys follows the imbalances between reactive oxygen species (ROS) and antioxidant systems and between the pathologic and protective arms of the RAS axis. The patholog [....] » Read More
The study of the association between cancer and diabetes mellitus (DM) has been under investigation for decades. Particularly, in the field of neurology and neurosurgery, increasing attention has been paid to comorbid DM in cranial tumor patients, namely those afflicted with the [....] » Read More
The metabolic syndrome is a provocative clinical entity that is characterized by several cardiometabolic risk aspects including obesity, hypertension, and insulin resistance. This confluence is associated with an augmented peril of type 2 diabetes and cardiovascular disease. Diab [....] » Read More
Points of Discussion: Prevalence of Diabetes, Effect of Diabetes on vascular dysfunction, Biomarkers targeting vascular dysfunction in diabetic condition, possible treatments. There are around 100 million people worldwide who have diabetes mellitus. 5% to 10% of people have type [....] » Read More
Dyslipidemia is the most common major modifiable risk factor for ASCVD. Low-density lipoprotein cholesterol There is unequivocal evidence that LDL-C is causally related to atherosclerosis. The era has come when we are able to stabilise the plaque, arrest the progression of [....] » Read More
Objectives: The gestational weight gain (GWG) and hyperglycemia are two key factors affecting adverse pregnancy outcomes among women with gestational diabetes mellitus (GDM). We aimed to investigate the combinatorial effect of abnormal glucose metabolism and GWG on adverse out [....] » Read More
When glucose-1phosphate is added to a primer in presence of an enzyme, starch phosphorylase the glucose molecules produce a polymer amylose. I suggest recreation of this in vitro reaction complex into in vivo set of reactions, removing excess toxic glucose molecules from the cell [....] » Read More
Title : Navigating obesity, diabetes, and behavior change: A case study of a successful physician-patient partnership
Gretchen Holmes, Memorial Hospital at Gulfport, United States
Prevalence of obesity and diabetes are on the rise and have been since 1999. Physicians are frustrated at the lack of compliance from patients around behaviour change and patients are frustrated with physicians because they often need more tools and guidance to achieve successful [....] » Read More