Title : Insights on role of nutraceuticals in Diabetes Mellitus and metabolic syndrome
Abstract:
The metabolic syndrome is a provocative clinical entity that is characterized by several cardiometabolic risk aspects including obesity, hypertension, and insulin resistance. This confluence is associated with an augmented peril of type 2 diabetes and cardiovascular disease. Diabetes is a majorly growing public health concern around the world. This disease has a high rate of mortality, morbidity, and long-term consequences, and it is still a significant risk factor for cardiovascular disorders. Diabetes is a leading cause of kidney failure, heart attacks, stroke, blindness, and amputation of lower limbs. Oxidative stress and systemic inflammation may play a vital role in the pathogenesis of diabetes mellitus, metabolic syndrome, and their vascular complications such as subclinical, low-grade inflammation, alteration in antioxidant status, and tenacious platelet activation. Several clinically used nutraceuticals have been evidenced to target the pathogenesis of diabetes mellitus and metabolic syndrome. These compounds include flavonoids, antioxidants, vitamins, conjugated linoleic acid, minerals, omega-3 fatty acids, α-lipoic acid, dietary fibers, and phytoestrogens, The major objective of this study is to acquire more information about the prevalence and factors that influence the usage of nutraceuticals by diabetic patients, as well as to provide a methodological agenda for the clinical research on nutraceuticals usage in diabetes mellitus and metabolic syndrome.
Keywords: Diabetes mellitus, metabolic syndrome, oxidative stress, inflammation, antioxidants.
