Title : Synthesis of trimecaine methyl iodide from trimecaine base by traditional and microwave methods
As the chemical industry is growing steadily, it is vital to develop environmentally safe processes that can belong to green chemistry. Hence, it is essential to synthesise thermal stable ionic liquids and organic ionic compounds and use methods that do not require much energy and time and have a high yield. This paper aims to compare different methods of synthesis of trimecaine methyl iodide from trimecaine base.
Trimecaine hydrochloride was used to produce trimecaine base. Then, methyl iodide was added to half of the trimecaine base, which was dissolved in benzene. The compound was then heated in reflux for 60 minutes to produce the trimecaine methyl iodide by N-alkylation reaction. Another half of the base is used in the microwave method. Methyl iodide was added to the trimecaine base, which was dissolved in benzene, and the compound was heated in a microwave oven with 80 Watt power for 1 minute 5 times. According to NMR and infrared spectroscopies, the yield of trimecaine methyl iodide by the traditional method (reflux) was 82.3%, while the yield of trimecaine methyl iodide by the microwave method was 86.6%. The microwave method is effective because it uses much less energy and time, and also, its yield is higher.
Audience Take Away:
- This paper shows that organic ionic compounds, such as trimecaine methyl iodide, can be synthesised by green chemical methods that can be much more efficient than traditional methods.
- Audience can use this knowledge in creating new methods of synthesis of organic compounds by using environmentally safe and economically efficient methods.
- Biologists can use trimecaine methyl iodide synthesised by microwave method to check its impact on the growth of plants as trimecaine hydrochloride is used for this purpose.
- Medical scientists and pharmacologists can use trimecaine methyl iodide synthesised by microwave method to check its anesthetic properties as trimecaine hydrochloride is used for this purpose.