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Bassam Alkazman, Speaker at Pharmaceutics Conferences
The University of Sydney, Australia
Title : Preliminary studies on phytochemical constituents of the leaves and fruits of Annona atemoya


Annona atemoya is a commercially important fruiting plant belonging to the Annonaceae family. It is widely cultivated in tropical and subtropical continents. It is also known as the custard apple which is a hybrid between two Annonaceae species: (Annona cherimola) and (Annona squamosa). A systematic review was published recently investigated the phytochemistry and bioactivities of A. atemoya. A total of 1055 abstracts were identified in the initial search and according to the inclusion and exclusion criteria, 32 articles were conducted in this systematic review. The outcomes of this review indicate that 18 studies examined the phytochemical constituents of various parts of A. atemoya and 14 studies investigated the biological activities in vivo (n = 5), in vitro (n = 7) and two studies discussed its in vitro toxicity. Moreover, the constituents of A. atemoya include alkaloids, flavonoids, terpenes and acetogenins, and these constituents possess cytotoxic, anti-angiogenic, hypolipidemic, antioxidant, anti-inflammatory and neuroprotective activities.

The leaves and fruits of two cultivars of A. atemoya (African Pride and KJ Pinks) were collected in July 2020 from a local farm in Queensland and kept on the bench for air drying at room temperature and well-ventilated area (3 days – 1 week). The leaves of both cultivars were extracted with three solvents started by hexane, ethyl acetate and ethanol for three days. The preliminary results of TLC and NMR experiments indicate the presence of annonaceous acetogenins in all extracts. Future studies will be focused on the isolation and characterization of these components and test their activity on various cancer cell lines.