Advertisement

x

International Precision Medicine Conference

April 19-21, 2021 | Orlando, USA

Scopus Indexed Conference
scopus
Holiday Inn Orlando SW Celebration Area, 5711 W. Irlo Bronson Memorial Highway, Kissimmee, FL 34746, USA
Phone : 1 (702) 988 2320
Toll Free: 1800–883-8082
Whatsapp: +1 (540) 709-1879
Email: precision@magnus-event.com
April 19-21, 2021 | Orlando, USA

Antonina Mitrofanova

International Precision Medicine Conference- Antonina Mitrofanova
Antonina Mitrofanova
Rutgers Cancer Institute of New Jersey, USA
Title : Pathway-centric approaches to uncover markers of treatment response in cancer patients

Abstract:

Prioritization of patients based on the risk of resistance to treatment plays a significant role in personalized therapeutic planning and improving disease course and outcomes. We have developed a series of computational algorithms to utilize patient molecular profiles to predict their favourable or poor response to therapy. We have demonstrated that a pathway-centric approach is superior compared to gene-level analysis alone. Further, we have shown that multi-level Big Data analysis to elucidate dysregulated pathways that govern therapeutic response is superior to using any single data type. We applied our approaches to chemotherapy resistance in lung adenocarcinoma and colorectal cancer, alongside tamoxifen resistance in breast cancer and have demonstrated their robustness, high accuracy, significant ability to predict treatment response and generalizability.  Importantly, our predictions were not affected by common co-variates or markers of overall disease aggressiveness. We propose that the identified pathway markers can be utilized to prioritize patients who would benefit from specific treatments and patients at risk of resistance that should be offered alternative regimens.

Biography:

Dr. Mitrofanova is an Assistant Professor in Biomedical and Health Informatics at Rutgers University, School of Health Professions. She received her PhD in Computer Science from NYU Courant Institute of Mathematical Sciences and PostDoctoral training in Computational Cancer Biology from Columbia University Cancer Center. Her main research interests are in developing computational algorithms to elucidate mechanisms of cancer progression and treatment resistance in cancer patients. Dr. Mitrofanova’s publications span Cancer Cell, Nature Communications, Cell Reports, Nature Cell Biology, PNAS, EBioMedicine, and Nature Communications Biology. She is a recipient of the NSF Computing Innovation Fellowship and a Prostate Cancer Foundation Young Investigator Award.

Watsapp