Title : Precious medicine in ambiguous diseases individualizing care in age-associated cardiovascular conditions
Precision-medicine is posed to make great advancements in diseases with predominant genetic and biomolecular underpinnings. However, its role in the much more burdensome age-associated conditions, specifically cardiovascular conditions, is still questionable. One major hurdle against advancements in this direction is the polygenic nature and phenotypic ambiguity of these conditions. As a result, despite their significance, the great advancements in mapping the human genome and the development of extensive biomolecular batteries will not be sufficient to resolve the complexity of age-associated conditions. Mapping the phenome, i.e. theoretically characterizing every biological process and component in the human body across time is our next challenge, and it is a much harder problem to crack, if at all. The theoretical framework of advanced phenotyping developed to understand the heterogeneity in human cardiovascular aging might provide insights to guide individualizing care in exaggerated forms of these processes manifesting in age-associated diseases. In this presentation, I aim to discuss the shortcomings of our existing clinical phenotyping, the reasons for these shortcomings, and methods to overcome them. A paradigm shift in our approach to clinical phenotyping from focusing on mortality predicters at populations level, to a much wider collection of deeper physiological descriptors coupled with developing novel, corresponding medical epistemological concepts are pre-requisites to any advancement towards solving the major health burden on humans.