International Precision Medicine Conference

April 19-21, 2021 | Orlando, USA

Scopus Indexed Conference
Holiday Inn Orlando SW Celebration Area, 5711 W. Irlo Bronson Memorial Highway, Kissimmee, FL 34746, USA
Phone : 1 (702) 988 2320
Toll Free: 1800–883-8082
Whatsapp: +1 (540) 709-1879
April 19-21, 2021 | Orlando, USA

Majd AlGhatrif

International Precision Medicine Conference- Majd AlGhatrif
Majd AlGhatrif
Johns Hopkins Bayview Medical Center, Baltimore
Title : Precious medicine in ambiguous diseases individualizing care in age-associated cardiovascular conditions


Precision-medicine is posed to make great advancements in diseases with predominant genetic and biomolecular underpinnings. However, its role in the much more burdensome age-associated conditions, specifically cardiovascular conditions, is still questionable. One major hurdle against advancements in this direction is the polygenic nature and phenotypic ambiguity of these conditions. As a result, despite their significance, the great advancements in mapping the human genome and the development of extensive biomolecular batteries will not be sufficient to resolve the complexity of age-associated conditions. Mapping the phenome, i.e. theoretically characterizing every biological process and component in the human body across time is our next challenge, and it is a much harder problem to crack, if at all. The theoretical framework of advanced phenotyping developed to understand the heterogeneity in human cardiovascular aging might provide insights to guide individualizing care in exaggerated forms of these processes manifesting in age-associated diseases. In this presentation, I aim to discuss the shortcomings of our existing clinical phenotyping, the reasons for these shortcomings, and methods to overcome them. A paradigm shift in our approach to clinical phenotyping from focusing on mortality predicters at populations level, to a much wider collection of deeper physiological descriptors coupled with developing novel, corresponding medical epistemological concepts are pre-requisites to any advancement towards solving the major health burden on humans.


Dr. AlGhatrif is an Assistant Professor of Medicine at Johns Hopkins and the Head of Human Cardiovascular Studies Unit at the Laboratory of the Cardiovascular Science/the National Institute on Aging. His research program is focused on employing advanced hemodynamic phenotyping techniques and computational models to better characterize individual patterns of cardiovascular aging and identify sub-phenotypes of aging-associated CV syndrome such as isolated systolic hypertension, heart failure with preserved ejection fraction, peripheral arterial disease and aortic aneurysm. In addition, his program explores the associations of individual patterns of cardiovascular aging with other aging-associated symptoms such as frailty and dementia.