Title: Green Successive Spectrophotometric Resolution Technique for the Analyzing Ternary Medicine Recommended to be Used During COVID-19 Pandemic- Purity Study
Abstract:
This study presents a novel green spectrophotometric analytical approach for the analysis of ACE-Proxyvon® tablet dosage form recommended to be used in managing the aggressive symptoms of COVID-19 attack as well as dealing with the tiresome post vaccination symptoms. This study focused on the analysis of ternary mixture containing aceclofenac (ACE), paracetamol (PAR) and rabeprazole (RAB) in challengeable ratio; 10:50:1, respectively in the presence of the PAR's potential degradation product; 4-aminophenol (4-AP). A Successful compromise was achieved between both resolution and in-silico sample enrichment techniques via employing successive manner based on the application of constant multiplication coupled with spectrum subtraction spectrophotometric method (CM-SS) to extract the parent spectrum for each proposed drug. The extracted parent spectra could be successfully used to monitor the purity of the drug and used effectively to detect counterfeit products. Synthetic mixtures and commercial medicine were constructively analyzed using the proposed technique while maintaining calibration graphs to be linear over ranges; 4.0-40.0 μg/mL for ACE, 2.0-14.0 μg/mL for PAR and 4.0-30.0 μg/mL for RAB. Additionally, methods' validation was confirmed via performing exhaustive statistical treatment of the experimental findings. Finally, method’s greenness profile was finally guaranteed through analytical greenness (AGREE) metric assessment tool.
