Enormous advances in the human health system have been achieved, however, diseases like cancer still required treatment options beyond therapeutic drugs, mainly surgery, and radiation. Most of the newly approved drugs have limited added therapeutic value and designing a brand-new drug can take up to 10 years and cost billions of dollars. The challenging question is how to make the existing drugs more effective. One possibility, if the concept of cure is deepened and expanded to include all elements of disease. Human is not only made of cells, tissues, and organs, but feeling and sensations are part of his nature. Linking mental state with physical health is essential to include all elements of disease. For this purpose, halalopathy has been introduced as a new model to integrate mind, behavior, an health, where psychology, spirituality, and rationality can be integrated together to generate a well-organized, regulated and connected health system. Halalopathy is based on mind-trust-drug and mind-trust-belief, compatibility between drug and belief would intensify trust and initiate a domino chain effect to activate the placebo effect, lower body’s entropy and increase potential energy, favorable circumstances will be created to promote the healing process, and with a prescribed therapeutic drug, complete recovery can be achieved. The healing approach may well affect non-genetic changes that human genome experiences as a result of interaction with the environment. Halalopathy acts as a source of education and motivation for patients to assume more personal responsibility for their health by adapting and enriching certain values to achieve more effective treatment. The concept promotes precise therapy and opens a new window for more effective treatment.