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2nd Edition of International Precision Medicine Conference

April 21-23, 2022

April 21 -23, 2022 | Las Vegas, Nevada, United States
2021 Speakers

Implementing a comprehensive precision medicine paradigm into primary care clinics

Gad Rennert, Speaker at Speaker for Precision Medicine Conferences 2021: Gad Rennert
Technion-Israel Institute of Technology, Israel
Title : Implementing a comprehensive precision medicine paradigm into primary care clinics

Abstract:

Precision medicine is promoted as a promising new medical approach leading to better health outcome. The term precision is used liberally to describe a wide variety of tools aimed at adding patient-specific information to the responsible physician. However, in-spite of point demonstrations of one technology or another in a specific medical situation, the employment of the full paradigm has never been demonstrated as leading to a better overall health.

Aim: Our project intends to demonstrate the benefit, or lack there-of, of evaluating all members registered in a primary care-clinic for a variety of markers, on the overall health status of the local community.

Methods: Unselected, full population cohort of adults insured in several multi-physician primary-care practices are invited to participate. This is done in the context of a Randomized Controlled Trial where clinics are selected and randomly allocated to genome-driven (intervention) clinics and usual-care clinics (controls). Preliminary steps include the training of the clinic medical teams to deal with results of extensive genomic and pharmaco-genomic tests. The target clinic population is also undergoing education about the new approach. Each participant is undergoing a genomic evaluation (spectrum: NGS panels, GWAS, WES, WGS), microbiome testing, as a planned use of wearable sensors. These test results are provided to the primary care physicians in the form of genetic risk-alleles of various diseases, pharmaco-genomic variants and informatics findings, potentially leading to medical action resulting in better health indicators (disease rates, use of health service, health economics, quality of life/satisfaction/adherence). A plethora of findings (prevalence of genetic variants, ethnic diversity, clinical associations with incidence/survival/disease-control) and insights (degree of acceptance by population, medical providers, health systems providers) is already available after recruiting the first 1500 participants.

Biography:

Prof. Rennert studied Medicine at Ben-Gurion University of the Negev, in Beer Sheba, Israel where he received his MD degree in 1984. He trained in Public Health/Preventive Medicine at Carmel Medical Center in Haifa, Israel, and further received a PhD degree from the University of Northern Carolina at Chapel Hill in 1988. His studies concentrate on understanding the genetic background of chronic diseases, especially malignancies and he has been involved in the publication of some 350 papers in molecular epidemiology/genetics, cancer control and public health policy. He is the Weissman Chair of Precision Medicine at the Technion-Israel Institute of Technology

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