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2nd Edition of International Precision Medicine Conference

April 21-23, 2022

April 21 -23, 2022 | Las Vegas, Nevada, United States
2021 Speakers

Importance of personalized precision nutrition and functional foods in healthy aging

Alexander G. Haslberger, Speaker at
University of Vienna, Austria
Title : Importance of personalized precision nutrition and functional foods in healthy aging

Abstract:

Health preservation and disease prevention are central objectives for establishing a healthy lifestyle and nutrition. Molecular mechanisms of aging, premature aging and the development of aging correlated complex diseases are step by step analyzed by scientific disciplines addressing the hallmarks of aging.  Studies using the epigenetic clock show the beneficial effects of fasting and diets on healthy aging and recently the definition of ageotypes indicates personal different drivers of aging. The concepts of healthy aging and attempts to increase longevity have resulted in remarkable innovations in precision medicine and precision nutrition. The highly individual regulation of gene expression and DNA integrity by environmental factors and nutrition is shown in the developments of genetics and epigenetics. Also, the detailed characterization of personal aspects of the human microbiome shows the need for systemic OMIC approaches to understanding pathological mechanisms and markers for them. The fields of nutrigenetics and nutri-epigenetics are analyzing mechanisms and markers in this area.

The use of molecular markers enables the detection of ongoing pathological mechanisms and interventions already before the onset of symptoms. Medical and nutritional- or dietary prevention and intervention are more often using personalized aspects. These developments result in preventive and personalized health care. Markers from the areas of genetics, epigenetics, microbiota, gene expression, and metabolomics need to be integrated for the assessment of optimized personal pre- and intervention. Medical drugs, functional foods, and nutrition are more and more used for personalized treatment of identified molecular mechanisms of concern. The terms personalized medicine and precision medicine or nutrition are somehow overlapping.

A worldwide fast increased awareness of ways for health preservation or recently the resistance against viral infections have boosted the development of functional foods and nutritional concepts. This includes also science-based ways of caloric restriction and fasting. Selected bacteria, algae, cells, or plants and their metabolites or extracts are screened for health-promoting effects and developed into functional foods. We report that the analysis of a combination of genetic-, CPG methylation- and miRNA markers in liquid biopsy samples can detect and monitor early cancers and the analysis of genetic, CPG methylation, and miRNA markers in blood spots can indicate personal dispositions to diets and sport and help to monitor the personal effects of epigenetic active nutraceuticals such as  EGCG, Phloretin or anthocyanins on aging relevant molecular mechanisms.

Biography:

Alexander G. Haslberger was born in 1956 March 10th Borne in Vienna, Austriacurrently working in Dep. for Nutritional Research, University of Vienna and he is a 2016 Visiting professor ship, Univ. Teheran. From 1983-1985 he completed his  Post doctoral fellow, microbial immunology, Sandoz Research Institute, Vienna. From 1985 -1992: Head of pharmaceutical research laboratory in the field of microbiology, Immunology and cell biology , Sandoz Research Institute, Vienna. In 1986 he worked as a Senior scientist, leader of working group and lecturing at the University of Vienna ; microbial immunology, food safety, ecology. From 2002- 2004 Research scientist, World Health Organisation, department for food safety, work on WHO study GM food safety. His main recent research projects are on ROS, DNA mutations in metabolic syndrome and epigenetic regulation of repair enzymes by Nutrition, FWF, end 12/ 2016 Bacterial diversity in the GI tract of immune- compromised consumers. Austrian National Bank Microbiota and Probiotics , FWF, Austria PHGEN, Public health genomics, EU research Network Metabolic syndrome and bacterial GI communities, FFG. He has Peer reviewed many publications from last 5 years.

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