HYBRID EVENT: You can participate in person at Las Vegas or Virtually from your home or work.

2nd Edition of International Precision Medicine Conference

April 21-23, 2022

April 21 -23, 2022 | Las Vegas, Nevada, United States
2022 Speakers

Methylating Agents as Rescue Adjunct Therapy to Chemotherapeutic Alkylating Medications for Improved Outcomes in Chronic Lymphocytic Leukemia: A Case Study and Protocol with National Implications

Bruce K Kowiatek, Speaker at Speaker for Personalized Medicine Congress: Bruce K. Kowiatek
Blue Ridge Community and Technical College, United States
Title : Methylating Agents as Rescue Adjunct Therapy to Chemotherapeutic Alkylating Medications for Improved Outcomes in Chronic Lymphocytic Leukemia: A Case Study and Protocol with National Implications

Abstract:

Although the non-enzymatic methylation of cytidine (C) by S-adenosylmethionine (SAM) and methylcobalamin  to 5-methylcytidine and its subsequent spontaneous deamination to thymidine (T) in DNA at physiologic pH and temperature has been implicated in some C to T point mutagenic cancers, cancers in general display a global hypomethylation of their DNA; SAM, therefore, sold as the over-the-counter (OTC) supplement SAM-e, as well as the OTC  methylcobalamin precursor cyanocobalamin may still possibly play a role as potential rescue adjunct therapies in certain cancers, particularly those treated with alkylating chemotherapeutic agents used in chronic lymphocytic leukemia (CLL), much in the same way that folic acid is used as a rescue adjunct therapy when using antifolate chemotherapeutic agents. Clinical trials in support of this proposal were set to begin just prior to the COVID-19 pandemic but have been indefinitely postponed; however, an ongoing case study employing this methylation protocol is currently underway and has, since its inception, also been implemented nationally, with its highly successful results presented here along with current updates.  

Biography:

Dr. Bruce K. Kowiatek earned his Bachelor’s in English Writing from the University of Pittsburgh in 1998, and his Doctorate in Pharmacy and Master’s in Business Administration from Shenandoah University in 2002. In addition to researching and investigating the origins of life for over 20 years, he has also published books and papers on a variety of topics, worked as a clinical pharmacist, and is currently full-time Allied Health Faculty at Blue Ridge Community and Technical College in Martinsburg, WV.

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