Title : Personalized and Precision Medicine (PPM) as a unique healthcare model to be set up to secure the human healthcare, wellness and biosafety through the view of public health
Abstract:
A new systems approach to diseased states and wellness result in a new branch in the healthcare services,
namely, personalized and precision medicine (PPM). To achieve the implementation of PPM concept, it
is necessary to create a fundamentally new strategy based upon the recognition of biomarkers of hidden
abnormalities long before the disease clinically manifests itself. NIH (Bethesda, USA) has included PPM
into a List of the Five Greatest Priorities of Development of Medicine and Healthcare Services in XXI
Century.
Each decision-maker values the impact of their decision to use PPM on their own budget and well-being,
which may not necessarily be optimal for society as a whole. To really understand PPM we would have to
understand the various fields of translational applications that provide the tools to exploit and practice PPM,
and genomics- and phenomics-related tools, in particular!
Improved patient (or persons-at-risk) outcomes with the application of the biomarker tests must consider
not only increased survival or quality of life, but also improved clinical decision support (CDS) & making
leading to the avoidance of unnecessary therapy or toxicity captured within the rapid learning system. So,
bioinformatics, artificial intelligence (AI), machine learning (ML) and biostatistics will be crucial in
translating those Big Data into useful applications, leading to improved diagnosis, prediction,
prognostication and treatment.
It would be extremely useful to integrate data harvesting from different databanks for applications such as
prediction and personalization of further treatment to thus provide more tailored measures for the patients
resulting in improved patient outcomes, reduced adverse events, and more cost effective use of the latest
health care resources including diagnostic, prognostic, preventive and therapeutic (targeted) etc.
Personalized aims and objectives exist at every stage of disease initiation and progression to develop a
Personalized Health Plan (PHP) addressing lifestyle, risk modification and disease management, and later,
Personalized Health Management & Wellness Program (PHMaWP). And a lack of medical guidelines has
been identified by responders as the predominant barrier for adoption, indicating a need for the development
of best practices and guidelines to support the implementation of PPM.
