HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

3rd Edition of International Precision Medicine Conference

March 17-19, 2025

March 17 -19, 2025 | Rome, Italy
2022 Speakers

Jinyuan Zhou

Jinyuan Zhou, Speaker at Precision Medicine Conferences - 2022
Johns Hopkins University School of Medicine, United States
Title : Protein-based amide proton transfer MRI: Neurological applications and standardization


Amide proton transfer (APT) imaging is a novel molecular MRI technique that generates image contrast based on endogenous cellular proteins in tissue. APT imaging is a specific type of chemical exchange saturation transfer imaging. Theoretically, the APT-MRI signal depends primarily on the mobile amide proton concentration and amide proton exchange rates (which are related to tissue pH). The APT technique has been successfully used for non-invasive pH imaging in stroke (where pH drops) and protein content imaging in tumor (where many proteins are overexpressed). In this talk, I will first talk about the basic principle of APT imaging at the protein level and review its current successful applications for the imaging of brain tumors, including the detection and grading of tumors, the assessment of treatment effect versus tumor recurrence, and the identification of genetic markers. Other clinical application examples, including imaging of stroke, Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury, will be briefly reviewed. Finally, I will introduce the challenging issues and the recent consensus recommendations for APTw imaging of brain tumors on 3T MRI systems.


Dr. Jinyuan Zhou is an MRI physicist. His research focuses on developing new in vivo MRI methodologies to study brain function and diseases. He earned his Ph.D. in physics from Wuhan Institute of Physics, Chinese Academy of Sciences. He performed a post-doctoral fellowship on in vivo MRI at the Johns Hopkins University, and  joined the Johns Hopkins faculty in 1999. He is currently a Professor in the Department of Radiology and Radiological Science. He has published  more than 150 peer-reviewed papers.