Title : 3D Bioprinting complicated large organs with a vascular system
Abstract:
Improvements in the Roll Porous Scaffold (RPS) 3D bioproduction technology will increase print density of 10−15 µm cells by ~20% up to ~1.5×10^8 cells/mL and purity of organoid formation by >17%. The use of 360 and 1200 dpi inkjet printheads immediately enables biomanufacturing with 10–30 µm cells in a single organoid with performance >1.8 L/hour for 15 µm layer thickness. The spongy bioresorbable ribbon for RPS technology is designed to solve the problems of precise placement, leakage and increasing in the number of instantly useable cell types and superior to all currently dominant 3D bioprinting methods in speed, volume, and print density without the use of expensive equipment and components. Potential of RPS for parallel testing of new substances not on animals, but using generated 3D biomodels “organ on a chip”. Solid organoids are more suitable for personalized medicine with simultaneous checking of several treatment methods and drugs, targeted therapy for a specific patient in vitro using the 3D composition of his personal cells, and selection of the most effective ones with the least toxicity. Overcoming the shortage of organs for implantation and personal hormone replacement therapy for everyone using printed endocrine glands based on their DNA. Roll Porous Scaffold is a revolutionary 3D bioprinting technology that offers a solution to the fundamental problems of 3D bioprinting without launching printers into space.