Title : Identification of multi omics-based prognostic biomarkers in KEAP1, NRF2 and/or CUL3 mutated human cancers
Abstract:
NRF2 is a transcription factor that forms a complex with its negative regualotor KEAP1 and CUL3. This complex leads the NRF2 to ubiquitination and proteosomal degradation. Reactive oxygen species stabilizes the NRF2 protein from KEAP1 retention and subsequently NRF2 transclocates in the nucleus and regulated the cytoprotetive genes. On the other hand, KEAP1, NRF2 and CUL3 mutations has been demonstrated to contributes to cancer cell survival and development and resistance to anticancer treatments. We carried out an integrated, multi-omics analysis of KEAP1, NRF2 and/or CUL3 mutated TCGA patients. Finally, we discovered the gene signatures associated with these mutations, prognostic genes which were highly correlated with the upregulation of the NRF2 pathway in different cancer patients. Our finding might be helpful to identify the early diagnosis of the NRF2 in cancer patients.
