HYBRID EVENT: You can participate in person at Paris, France or Virtually from your home or work.
ICOR 2016

Maciej Harat

Maciej Harat, Speaker at Cancer Congress
The Franciszek Lukaszczyk Oncology Center, Poland
Title : Pre-irradiation tumour volumes defined by MRI and dual time-point FET-PET for the prediction of glioblastoma multiforme recurrence: a prospective study

Abstract:

Comparison of pre-treatment MRI and dual time-point 18F-fluoroethylthyrosine-PET (FET-PET)-based target volumes with patterns of primary glioblastoma multiforme failure following radiotherapy with temozolomide is done. Established that FET-based tumor volumes measured 10 minutes after radionuclide injection were, on average, larger than tumor volumes measured 60 minutes after radionuclide injection. PET volumes were significantly larger than corresponding MRI-based volumes. MRI and FET concordance for the identification of glioblastoma GTVs was poor (mean uniformity index 0.4). 74% of failures were inside primary PET volumes, with no solitary progressions inside the MRIdefined margin +20 mm but outside the PET-defined area detected. Therefore conclude that the size and geometry of GTVs differed in the majority of patients, PET volume depends on time after radionuclide injection, and FET-PET better defined failure site than MRI alone.

Watsapp