Abstract:
Purpose: To assess the diagnostic performance of WB-DWIBS compared to FDG-PET-CT in assessment of breast cancer patients.
Method and Materials: 50 patients with pathologically proven breast cancer underwent both F-18-FDG PET-CT and WBMRI/DWIBS. The sequences acquired are whole body DWI, coronal T1 and coronal STIR. FDG-PET/CT was performed on an integrated PET-CT system. Whole body F18 FDG-PET CT was performed using standard technique. Both F-18-FDG PET-CT and WB-MRI/DWIBS were independently interpreted using visual qualitative and quantitative analysis in the term of SUV max and ADC value respectively. Using pathological data and / or combined clinical / radiological follow up as a reference standard, Sensitivity, specificity, PPV, NPV and overall accuracy were estimated for both techniques.
Results: F-18 FDG PET-CT demonstrated slightly higher specificity indices than MR-DWIBS while the MR-DWIBS displays higher sensitivity indices than FDG PET CT in particular in loco-regional assessment. In addition, high sensitivity indices of DWIBS were depicted in assessment of nodal and bone marrow lesions with fair specificity indices. A high degree of agreement also existed between DWIBS and PET CT with little better accuracy of FDG PET CT more appreciated in the pulmonary lesions assessment.
Conclusion: WB-MRI/DWIBS is a promising tool in evaluation of cancer patients in particular breast cancer.
CLINICAL RELEVANCE/APPLICATION Easy technique for detection and assessment of metastasis with no radiation exposure.
