ICC 2019

Mukasa Eliphaz

Mukasa Eliphaz, Speaker at Oncology Conferences
University of the Witwatersrand, South Africa
Title : Formulation of a natural intraoral dispersible film (IDF) for intraoral delivery of various natural drugs using edible rice paper film as the carrier vehicle

Abstract:

Background: At present, pharmaceutical researchers are focusing on instantaneous intraoral dispersible technologies as novel drug delivery systems because; they have outstanding advantages over the traditional oral and parenteral routes of drug administration. Some essential natural drugs have low oral bioavailability due to extensive first pass metabolism and pre systemic degradation in the gastrointestinal tract.
Purpose of Study: This research, addresses these problems by formulating a cheap rice paper Intraoral Dispersible Film (IDF). IDFs are effective and could improve the bioavailability of some natural drugs.
Methods: In this study, formulation was optimized using the experimental factorial design. The IDFs were loaded with model, natural, anti-cancer drugs, Resveratrol and Curcumin with low oral bioavailability. They were evaluated for thickness, folding endurance, swelling behaviour, among others. These related to drug release properties. Permeation was evaluated using the pig mucosal membrane mounted on a Franz diffusion cell, and taste testing was done to determine acceptability using a taste panel. Sixteen formulations showed variations in disintegration time, thickness, Tensile strength and permeation profiles.
Results: The key finding is, ex vivo release profiles of the optimized formulation revealed first order release and later zero order. Published results were that When Curcumin was given orally at a dose of 2 g/kg to rats, a maximum serum concentration of 1.35±0.23 µg/ml was observed at time 0.83 hours, whereas in humans the same dose of Curcumin resulted in either undetectable or extremely low (0.006±0.005 µg/ml at 1 hour) serum levels (Siebenand, 2010). Boocock (Boocock et al., 2007) reported Cmax for two separate mono-glucuronide metabolites, for a total glucuronide metabolite concentration ~7.5 µM following a single 5.0 g oral dosage of Resveratrol. In this study, after permeation, a concentration of 6.73mg/ml of Resveratrol and 0.061mg/ml of Curcumin were detected after 2 hours of the experiment after administration of 20 mg of each of the drugs. Conclusions: Therefore, it is evident that rice paper IDF could efficiently deliver natural drugs into the blood.

Biography:

Mukasa Eliphaz has worked at Medipharm Industries EA Ltd. Uganda factory for 15 years. He is specialized in cGMP and ORS Manufacture. He has studied at Mulago Hospital School of Dispensing for a Diploma Pharm in 1988. He taught at Mulago Paramedical School for 2 years. He has attended a Clinical Instructor’s course at Mbale Health Manpower Development Centre in 1999 and worked as an Assistant Drugs Inspector at Uganda National Drug Authority for 7 years. He has also attended NIPER Chandigarh India for Assessment of quality of Pharmaceuticals. He did his BPharm in 2012 at NMMU Port Elizabeth South Africa. He has worked at Johannesburg General Hospital Charlotte Maxeke for his Pharmacist Internship in 2013. Presently he is an MPharm student at the University of the Witwatersrand, SA 2013 to 2016. Worked as a community Service Pharmacist in 2017 at Nessie Knight Hospital Sulengama Qumbu Eastern Cape, South Africa, Now in 2018 – 2019 working as a post community service Pharmacist in Qumbu Community Health Centre, Qumbu Eastern Cape, South Africa.

Watsapp