HYBRID EVENT: You can participate in person at London, UK or Virtually from your home or work.
ICC 2019

Jens Claus Hahne

Jens Claus Hahne, Speaker at Oncology Conference
The Institute of Cancer Research, United Kingdom
Title : Use of microRNAs as biomarkers in cancer patients

Abstract:

MicroRNAs are pivotal regulators for RNA silencing and post-transcriptional regulation of gene expression under physiological as well as pathological conditions. MicroRNAs can be detected in tissues and in most biologic fluids including serum, plasma and urines. Secreted microRNAs are either incorporated into microvesicles or circulate bound to proteins. In both cases microRNAs are protected from RNase degradation so that they may remain intact for long periods of time. Therefore they might represent potential new biomarkers. We analysed expression of 800 miRNA’s using nCounter Nanostring technology in 3-D cell culture models (organoids), formalin fixed paraffin embedded tissues as well as plasma and urine from cancer patients. Potential clinical applications of microRNA detection for cancer patients’ management will be discussed.

Biography:

After studying general chemistry and biochemistry at the Albert-Ludwigs-University Freiburg i.Br. (Germany) I got the PhD in biochemistry from the same university. During my PhD work I was trained in virology, cell- and molecular-biology. During several postdoc positions [Department of Molecular Pathology at the University of Bonn (Germany), Charite Berlin (Germany), Department of Gynaecology and Obstetrics at the University of Wuerzburg (Germany)] I received a broad training and knowledge in molecular pathology and cancer research. At the moment I am working in the Department of Molecular Pathology at the ICR (London, UK). I have published more than 60 papers in reputed journals and has been serving as an editorial board member of repute.

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