ICC 2022

George Zachos

George Zachos, Speaker at  Cancer Congress
University of Crete, Greece
Title : The abscission checkpoint: a protector of chromosomal stability


Increasing evidence indicates that cancer metastasis is regulated by specific genetic pathways independent of those controlling tumorigenesis and cancer growth. WASF3, a Wiskott-Aldrich syndrome protein family member, appears to play a major role not only in the regulation of actin cytoskeleton dynamics but also in cancer cell invasion/metastasis. Recent studies have highlighted that WASF3 is a master regulator and acts as a pivotal scaffolding protein, bringing the various components of metastatic signaling complexes together both spatially and temporally. Herein, targeting WASF3 at the levels of transcription, protein stability, and phosphorylation holds great promise for metastasis suppression, regardless of the diverse genetic backgrounds associated with tumor development. This review focuses on the critical and distinct contributions of WASF3 in the regulation of signal pathways promoting cancer cell invasion and metastasis.


George Zachos completed his PhD at the University of Crete in 1997. He then received postdoctoral training in the Beatson Institute for Cancer Research, Glasgow, U.K. before moving, in 2008, to the Department of Biology, University of Crete, Heraklion, Greece as an Assistant Professor in Cell Biology. In 2015, he became Associate Professor and continues to hold this position today. Discoveries from the Zachos lab have identified mechanisms that regulate the fidelity of chromosome segregation in mitotic cell division in higher eukaryotic cells. He has published over 40 papers in leading scientific journals and his work has received ~2,000 citations.