Abstract:
In this study Mg_(1-x) Co_x Fe_2 O_4 (0≤x≤1 with ?x=0.1) nanoparticles were synthesized by chemical co-precipitation method and annealed at 200oC, 400oC, 600oC, and 800oC in order to study their potential applications for hyperthermia therapy of cancer. The structural properties of the materials were investigated by X-ray diffractometer (XRD), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR). The observed and calculated lattice parameter, the particle size, the X-ray density, the ionic radius of the tetrahedral and octahedral site, the hopping length of the tetrahedral and octahedral site, the bond length of the octahedral and tetrahedral site, cation-cation distance, and cation-anion distance increases with an increase in Co^(2+) content and annealing temperature. From FTIR spectroscopy we observed that the frequency band of both tetrahedral and octahedral site shifted towards the lower frequency region with an increase in Co^(2+) content and annealing temperature due to the extension of the covalent bond. Force constant decreases with an increase in Co^(2+) content and annealing temperature. The thermal characteristics of the Mg_(1-x) Co_x Fe_2 O_4 nanoparticles were investigated by gravimetric analysis (TG) and differential scanning calorimetry (DSC) measurement. Exothermic peak found near 400oC of the TG curve is a clear indication of good crystallinity which was also confirmed by XRD. The magnetic properties of our investigated sample were measured by the Physical Property Measurement System (PPMS). The saturation magnetization, coercivity, remanent magnetization, and anisotropy constant of the Mg_(1-x) Co_x Fe_2 O_4 nanoparticles increase with an increase in Co^(2+) content and annealing temperature. The hyperthermia properties of Chitosan-coated Mg_(1-x) Co_x Fe_2 O_4 nanoparticles annealed at different temperatures were investigated. Specific loss power (SLP) increases with an increase in Co^(2+) content. Initially, the value of SLP increases with increasing particle size but after a certain value of particle size the value of SLP fall abruptly with an increase in particle size. The peak of the SLP curve found at a comparatively lower value of particle size with an increase in Co^(2+) content. The higher the value of SLP, the more efficient the nanohybrid will be for hyperthermia therapy of cancer.
Audience Take Away Notes:
- The audience will learn about a new approach of cancer treatment called hyperthermia, which is a minimally invasive technique. This technique is applicable for localoized or deeply seated tumor. This is a nanohybrid based therapy. Audience will be able to learn how functionalization and structural adjustment of the nanohybrids enhance the ultimate engineering parameter called specific loss power for successful development of the media for hyperthermia treatment of cancer
