Hepatocellular carcinoma (HCC) is one of the most lethal malignancies for human. Early diagnosis of HCC is crucial in reducing the mortality of the disease. In this study, a panel of 9 fusion transcripts in the serum samples from 136 individuals using TaqMan qRT-PCR was analyzed. [....] » Read More
Vibrational optical coherence tomography (VOCT) is a new technique to optically image and measure the resonant frequency of cells, blood vessels, papillary collagen, and fibrotic tissue in the skin and other soft tissues. The technique uses low levels of infrared light (0.1mW) fo [....] » Read More
Blasts in acute myeloid leukemia (AML) can show differentiation toward various lineages, including monocytic, erythroid, megakaryocytic, and plasmacytoid dendritic cell lineage. The incidence and clinicopathological features of mast cell (MC) differentiation in AML is large [....] » Read More
Chromatin bridges are strings of mis-segregated chromatin connecting the anaphase poles or daughter nuclei in mitotic cell division and can arise from incomplete DNA replication or decatenation, or from dicentric chromosomes generated by end-to-end chromosome fusions. Chromatin b [....] » Read More
A case of about-80-year-old-female is herein presented. She felt palpable mass in her right breast of about 10mm-in-diameter before 1 year for our exams. In this time, she felt the mass is larger and larger. Hence, she came to our hospital for further examinations and treatments. [....] » Read More
This project engages mathematical models to explore interactions between healthy cells and cancer cells. Another focus of the research is to investigate how competitive interaction among cells can be affected by the application of a chemotherapy agent in a dose-dependent mann [....] » Read More
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is prone to metastasis and therapy resistance. Due to its aggressive nature and limited availability of targeted therapies, TNBC isassociated with higher mortality compared to other forms of breast cancer. To [....] » Read More
Breast cancer is the most commonly diagnosed malignancy among women worldwide, accounting for approximately 30% of all new cancers in females annually. Risk factors include prolonged estrogen exposure (e.g., early menarche, late menopause, hormone replacement therapy), advancing [....] » Read More
Among the emerging strategies in cancer immunotherapy, individualized mRNA-based vaccines have garnered significant attention for their ability to stimulate a robust tumor-specific immune response by targeting patient-specific immunogenic tumor mutations. Although the focus of ca [....] » Read More
Immune checkpoint inhibitors (ICIs), particularly PD-1 inhibitors such as pembrolizumab, have transformed the management of advanced melanoma. However, ICIs are associated with immune-related adverse events (irAEs), which can affect various organs, including the endocrine system. [....] » Read More
Immune checkpoint inhibitors (ICIs), particularly PD-1 inhibitors such as pembrolizumab, have transformed the management of advanced melanoma. However, ICIs are associated with immune-related adverse events (irAEs), which can affect various organs, including the endocrine system. [....] » Read More
Background: The poor prognosis of breast cancer in Sudan could be due to delayed treatment and diagnosis at an advanced stage. Our study aimed to assess the extent of delays from onset of symptoms to treatment in Sudanese women with breast cancer, as well as identify factors co [....] » Read More
Background: Among patients admitted under general medicine, those with a background of cancer often admitted for non-oncological reasons. Their past experiences and on-going care needs may influence what they expect from hospital care. These un-met needs are not always fully addr [....] » Read More
Chromatin bridges are strands of incompletely segregated DNA connecting the anaphase poles or daughter nuclei. Chromatin bridges can arise from incompletely replicated DNA, defective resolution of DNA catenates or dicentric chromosomes which are formed by chromosome fusions. If u [....] » Read More
Even through the esophageal câncer has innumerable treatment options, its prognosis is still unsettled.Because esophagectomy is rarely curative, others therapies ,such as chemoradiation emerging in advanced disease followed or not surgery.The salvage esophagectomy is an alt [....] » Read More
Although malignant neoplasms of the esophagus remain a very common disease, their diagnosis might often come late,which explains why 50% of patients require palliative treatment.The ideal scenario would be the per-formance of procedures that provided an adequate quality of life a [....] » Read More
Breast cancer is the most common malignancy in women worldwide and remains a leading cause of câncer related mortality. While the immune system plays key role in controlling tumor progression, it is often suppressed in breast cancer. Dendritic cells (DCs), which connect inn [....] » Read More
Squamous cell carcinoma (SCC) is the most common malignant neoplasm of the oral cavity. According to literature, SCC of the lower alveolus account for 7.5 to 17.5% of all the oral cancers. Carcinoma of the lower alveolus is treated mainly by surgery followed by adjuvant therapy [....] » Read More
Introduction: Cervical cancer is the second most common cancer in Indian women, constituting 22.86% of all female malignancies. Neuroendocrine carcinoma (NEC) is a rare subtype of cervical cancer, accounting for approximately 1.4% of all cervical malignancies. Thes [....] » Read More
Objective: It remains unclear whether the priority of nodal dissection is different depending on Types II and III. Methods: The priority was evaluated by the therapeutic index, calculated by multiplying of the incidence of metastasis to each station by 5-year survival rate. [....] » Read More
Colorectal cancer (CRC) is one of the most common malignant tumors in the world. The 2022 China Cancer Statistics Report shows that the incidence and mortality of colorectal cancer in my country ranks second and fouth among all malignant tumors, respectively. Among them, about 15 [....] » Read More
This presentation discusses biosensor detection of ovarian cancer (OC). Personalized medicine offers a promising strategy for tailoring OC treatment to an individual’s genetic makeup and specific cancer subtype. This precision-based approach requires consideration of all pa [....] » Read More
MHC class I complexes can present antigenic peptides that have a sequence produced by post-translational mechanisms such as peptide splicing. Some examples of tumour-associated spliced epitopes have been investigated for their immunogenicity in the context of cancer so far. We de [....] » Read More
The future of cancer management is being reshaped by a convergence of technologies that not only transform diagnosis and treatment, but also the way we understand tumor biology, interact with patients, and design clinical trials (AI, blockchain, supercomputing, and medical device [....] » Read More
The rapid advancements in artificial intelligence (AI) have ushered in a new era of possibilities within healthcare, particularly in the detection and treatment of cancer. AI's ability to process and analyze vast amounts of medical data with precision has the potential to rev [....] » Read More
Aim: The aim of this study is to develop a clinically reliable prediction model for skin graft failure in skin cancer patients undergoing full-thickness skin graft (FTSG) or split-thickness skin graft (SSG). The primary objective is to identify key predictors of graft failure and [....] » Read More
Skin grafting is a key reconstructive technique following skin cancer excision. Many patients are on anticoagulation or antiplatelet therapy, raising concerns about skin graft failure due to bleeding and impaired wound healing. This study evaluated the failure rates of full-thick [....] » Read More
Introdcution: In-transit metastases (ITM) in melanoma is a type of locoregional metastasis found between the primary tumour site and the regional draining lymph node. Treating ITM can be a challenge; some recur after surgery alone and others are unresectable at presentation. Immu [....] » Read More
Background: Artificial Intelligence (AI) is playing an expanding role in public healthcare because of its greater precision, efficiency, accessibility, and potential to reduce costs. This study investigates how AI can support healthcare systems by improving diagnostic accuracy, o [....] » Read More
Aim: With the rising number of prostate cancer patients needing androgen deprivation therapy (ADT), especially with new monthly gonadotropin-releasing hormone (GnRH) antagonist injections, our province became the first in Canada to implement an off-site injection program. The g [....] » Read More
Introduction: War and armed conflict severely disrupt cancer care systems by destabilizing infrastructure, draining financial resources, and displacing healthcare personnel. Hospitals and clinics may become unsafe or inaccessible due to bombardment, military occupation, or e [....] » Read More
Background: The progression pathway of Merkel cell carcinomas (MCCs) remains a subject of ongoing debate, particularly regarding whether these tumors tend to metastasize first to lymph nodes or directly to distant organs. Clarifying this pattern is vital for understanding disease [....] » Read More
Introduction: Modern cancer treatments often lead to a wide range of acute side effects, such as nausea, fatigue, pain, and infections that significantly impair daily functioning. Long-term complications, including neuropathy, hormonal imbalances, infertility, and emotional distu [....] » Read More
Background: Central nervous system (CNS) tumors are categorized as primary or secondary, with metastatic tumors being more common. They contribute significantly to morbidity and mortality. Over the past decade, notable advances have emerged in their management. Methods: A comp [....] » Read More
Background: Sexual dysfunction is a prevalent yet often overlooked issue among cancer patients, significantly affecting their quality of life, emotional well-being, and intimate relationships. Despite the high prevalence (87%) of sexual dysfunction among cancer survivors, it [....] » Read More
Sexual health in cancer care is often overlooked. This study examines oncology nurses’ knowledge and practices regarding sexuality care, identifying barriers and facilitators. A Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)-guided search of Sco [....] » Read More
Objectives: Human papillomavirus (HPV) is the major etiological agent of cervical cancer, a leading cause of morbidity and mortality in women worldwide; screening strategies for reducing the burden of HPV-mediated carcinogenesis are emerging as effective means for cervical cancer [....] » Read More
The rising interest in innovative methods of cancer immunotherapy has prompted research into the immunomodulatory mechanisms of natural and synthetic substances. Aim: The goal of this study was to assess chrysin immune-stimulating and pro-apoptotic effects on tumor growth and [....] » Read More
Title : Role of mRNA genomics technology in cancer screening, diagnosis, prognosis, precision medicine, and gene therapy
Rajvir Dahiya, University of California San Francisco, United States
Current cancer screening methods—radiological imaging, DNA-based tests, and pathological assessments—often fail to detect malignancies at early stages. Despite technological advances, gene-based diagnostics specifically designed for early cancer detection remain limit [....] » Read More
Title : Update on PSMA PET scans: Initial and salvage treatment of nodal/distant metastases in prostate cancer
Patricia Tai, UpToDate, Canada
This update concerns the prostate-specific membrane antigen (PSMA) positron-emission tomography (PET) and key controversies in managing nodal and distant metastases in prostate cancer. PSMA PET is increasingly favored over conventional imaging techniques, yet treatment decisions [....] » Read More
Title : Personalized and Precision Medicine (PPM) through the view of biodesign-inspired translational research: An option for clinical oncologists, caregivers, and consumers to realize the potential of genomics-informed care to secure human biosafety
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). Meanwhile, the era of genomics-based medicine and thus genomics biomarkers promises to provide molecular tests that will pe [....] » Read More
Title : First-in-human phase II clinical trial of multiplex intratumoral immunotherapy (MITI) with RPT-01-5001 in patients with metastatic solid cancer (Abscopal 5001 trial)
David Boswick, Rampart Health, United States
Background: Little is known of the synergy of combination intratumoral immunotherapy and cancer ablation. We undertook a Phase II Trial (Abscopal 5001; NCT04713371) for patients with metastatic solid cancer to assess the safety and efficacy of cryoablation with concurrent injecti [....] » Read More
Title : Photodynamic therapy: First Canadian report of healing radiation-induced skin ulcers and implication for dentists, oncologists, family doctors and nurse practitioners
Patricia Tai, UpToDate, Canada
Introduction: Photodynamic therapy (PDT) had been used for benign and malignant skin lesions for some time. It can disinfect caries dentin before restoration or oral tissues before or during surgical procedures, treat denture stomatitis, and oral candidiasis in immunocompromised [....] » Read More
Title : Squamous differentiation in sinonasal tumours: A diagnostic pitfall
Dhuha Al Sajee, The University Health Network, Canada
Malignant tumors of the sinonasal tract account for approximately 3% of all head and neck malignancies. These tumors typically carry a poor prognosis. Diagnosis can be particularly challenging due to the small size of biopsy samples, crush artifact, and overlapping histologic and [....] » Read More
Title : Atypical presentation of Rosai-Dorfman disease with extensive cervical and mediastinal lymphadenopathy
Doaa Abdalla, University Hospitals of Leicester NHS Trust, United Kingdom
Background: Rosai-Dorfman Disease (RDD) is a rare condition often regarded as a benign histiocytic disorder that predominantly affecting children and young adults. Clinical presentation of RDD can mimic malignancy, making timely diagnosis and accurate management crucial. Case [....] » Read More
Title : Anomalous hepatic artery in liver transplantation for malignancy: Prevalence and surgical implications
Mohammed Ahmed, Kettering General Hospital, United Kingdom
Background: Anomalous course of hepatic arteries is common and present important considerations during liver transplantation (LT), particularly in patients with hepatic malignancies. Understanding their impact is essential for surgical planning and optimizing outcomes. Methods [....] » Read More
Title : Risk stratification and prediction of breast cancer locoregional recurrence current approaches and gaps
Seohyun Lee, University Hospitals of Leicester NHS Trust, United Kingdom
Background: Locoregional recurrence (LRR) in breast cancer remains a significant concern in breast cancer survivors, impacting their prognosis and guiding subsequent treatment. Accurate risk stratification and prediction tools and models are substantial for personalised care and [....] » Read More
Title : A rare case of mixed small cell and sarcomatoid carcinoma of the renal pelvis
Anjana Kalladathil Sreenivasan, Musgrove Park Hospital, United Kingdom
Invasive urothelial carcinoma is the most common malignancy of the renal pelvis, often exhibiting variant histology or divergent differentiation. Mixed small cell and sarcomatoid carcinoma of the renal pelvis is an exceedingly rare and aggressive entity with limited literature [....] » Read More
Title : Ivabradine for cancer therapy-related cardiovascular toxicity (CVR-CVT)
Yuko Harada, Kawasaki Municipal Ida Hospital, Japan
Introduction/Purpose: The mortality rate of cancer patients has been decreasing; however, patients often suffer from cardiac disorders due to chemotherapy or other cancer therapies (e.g., cancer therapy-related cardiovascular toxicity, CVR-CVT). Therefore, the field of cardio-onc [....] » Read More
Title : The molecular biology of alpha-fetoprotein - A biomarker of liver cancer
Ratan Kumar Sarkar, Independent Researcher, India
To stop cancer development the prime target would be intercept of electro-gravitational impulses(0.0107 or 0.0106 unit) entering into the cell system. A difference of 0.0001(1) is natural in directional biology. I shall determine the interplay of lunar time(183 or 0.3477 or 777), [....] » Read More
Title : Role of prognostic factor in oral squamous cell carcinoma - A single institute experience
Manmohan Agrawal, Pushpadi Cancer Care Centre, India
Squamous cell carcinoma is the most common tumor of oral cavity. The outcome of the Patient’s treatment depends not only on the stage but also on various prognostic parameters. They are: Stage grouping, Extra nodal spread, Depth of invasion, PNI, Worst pattern of invasion, [....] » Read More
Title : The next generation cancer treatments - The role of quantum biology, genomics and artificial intelligence
K R Muralidhar, Karkinos Healthcare, India
Aim: This study delves into cutting-edge cancer treatments by leveraging advancements in quantum biology, genomics, and artificial intelligence. Additionally, it investigates the integration of AI- generated auto-contours, using deep learning segmentation, into diverse treatment [....] » Read More
Title : Post bone marrow transplant colitis - Histopathological clues to differentiate primary GVHD from CMV colitis
Neema Tiwari, PGICH, India
Introduction: Histopathology has played a major role in understanding the pathophysiology and aiding in the diagnosis and management of graft-versus-host disease (GVHD). For all the cases undergoing transplant the post-transplant recovery depends on a multitude of factors and one [....] » Read More
Title : Arabitect: Microwave-assisted green synthesis of graphene oxide quantum dots from Coffea arabica L. as fluorescent probe with cytotoxic effects for selective and sensitive novel macroscopic detection of HCT166 human colon adenocarcinoma
Gared Arthur S Tribunalo, Science and Technology Education Leaders in Learning and Research, Philippines
Colon cancer remains one of the most elusive cancers to detect, as it often shows no symptoms in its early stages. Additionally, its gold-standard diagnostics carry substantial risks, while existing cancer detection studies are narrowly focused on the microscopic scale, leaving a [....] » Read More
Title : Hybrid deep learning model for breast cancer classification using Kaggle’s breast cancer dataset
Maryam Khaleghian, Payame Noor University of Tehran, Kish International Campus, Iran (Islamic Republic of)
Breast cancer remains one of the most prevalent and life-threatening diseases, with early detection playing a crucial role in improving patient outcomes. Deep learning techniques have emerged as powerful tools for automating cancer diagnosis, yet challenges persist in optimizing [....] » Read More
Title : Hybrid deep learning architectures for enhancing cancer diagnosis
Farasat Veisi, Payame Noor University of Tehran, Qeshm International Campus, Iran (Islamic Republic of)
Lung cancer is among the most fatal cancers, necessitating advanced diagnostic tools for early detection. This study investigates the performance of a novel deep learning approach combining EfficientNet with an attention-based Transformer model to classify lung cancer images from [....] » Read More