Abstract:
Cancer cells are characterized by overhydrated state and contain more than 90% of water (Kircuita et al., 1973). Cell overhydration serves as one of the diagnostic parameters for carcinogenesis (Damadian 1971). However, the nature of metabolic mechanism, the dysfunction of which causes in cancerous cells has not been elucidated yet as well. The discovery of our laboratory, that the electrogenic Na/K pump –induced net water efflux from the cell is fundamental mechanism controlling semipermeable properties of cell membrane, dysfunction of which in common consequence of cell pathology, including cancer.
Two quantum-sensitive families of high affinity (10-11-10-10M and 10-9-10-8M) ouabain sensors in cell membrane have been identified which unlike to low affinity to ouabain(>10-7M ), having inactivation effect on Na efflux from the cells, they have activated effect on Na efflux from the cells, accompanied by water efflux from the cells. The highest affinity sensors by activation of cGMP-stimulated Ca efflux from the cell stimulating of Na/K pump while and receptors with middle affinity stimulate the cAMP-activated Na/Ca exchange in reverse(R),mode controlling Na gradient on membrane by pushing out Na and decreasing membrane permeability for these ions.
The dysfunction of cGMP-dependent Ca efflux from the cells leading to cAMP-dependent R Na/Ca exchange -induced elevation intracellular Ca is suggesting as a primary mechanism for cell pathology, including cancer and cGMP-stimulated Ca efflux from the cell as effective tool for earlier periods carcinogenesis. target for tumor therapy
Audience Take Away Notes:
- The audience will be able to learn by lecture and publication materials in Research gate
- This research helps to other faculty to expand their research or teaching
- This provides a practical solution to a problem that could simplify or make a designer’s job more efficient
- It will improve the accuracy of a design, or provide new information to assist in a design problem
Other benefits:
The sGC as a novel target for cancer therapy.
Cell overhydration as earlier diagnostic parameter for carcinogenesis.
