Abstract:
Innate lymphoid cells (ILCs) have emerged as pivotal players in the immune system, with their roles extending far beyond traditional innate immunity. Recent advances in immunology have highlighted the significant influence of ILCs on tumor development, progression, and response to therapy. Here, we will explore the latest findings on how ILCs interact with the tumor microenvironment, modulate immune responses, and contribute to the dynamic landscape of cancer biology. We will delve into the mechanisms by which ILCs can either suppress or promote tumor growth, depending on the context, and discuss the potential of targeting ILCs as a novel therapeutic strategy in cancer treatment. By unraveling these complex interactions, we aim to uncover new avenues for immunotherapy and precision medicine, positioning ILCs at the forefront of cancer research and therapy.
Audience Take Away Notes:
- The multiple roles of ILCs in tumor biology: How different subsets of innate lymphoid cells can either promote or inhibit cancer development depending on the tumor microenvironment.
- Mechanisms of ILC interaction with the tumor microenvironment: The specific ways in which ILCs influence immune responses within tumors, including their impact on immune surveillance and tumor growth.
- Therapeutic potential of targeting ILCs: Insights into how manipulating ILC activity could lead to new cancer treatments, either by enhancing anti-tumor immunity or reducing tumor-supportive functions.
