HYBRID EVENT: You can participate in person at Baltimore, Maryland, USA or Virtually from your home or work.
Ran Sun, Speaker at Cancer Conferences
Chongqing Jiulongpo People’s Hospital, China


Breast cancer metastasis can happen even when the primary tumor is relatively small. But the mechanism for such early metastasis is poorly understood. Herein, we report that neurotrophin 4 (NTF4) plays a dual role in breast cancer proliferation and metastasis. Clinical data showed high levels of NTF4, especially in the early stage, to be associated with poor clinical outcomes, supporting the notion that metastasis, rather than primary cancer, was the major determinant of breast cancer mortality for patients. NTF4 promoted epithelial-mesenchymal transition (EMT), cell motility, and invasiveness of breast cancer cells in vitro and in vivo. Interestingly, NTF4 inhibited cell proliferation while promoting cellular apoptosis in vitro and inhibited xenograft tumorigenicity in vivo. Mechanistically, NTF4 elicited its pro-metastatic effects by activating PRKDC/AKT and ANXA1/NF-κB pathways to stabilize SNAIL protein, therefore decreasing the level of E-cadherin. Conversely, NTF4 increased ANXA1 phosphorylation and sumoylation and the interaction with importin β, leading to nuclear import and retention of ANXA1, which in turn activates the caspase-3 apoptosis cascade. Our findings identified an unexpected dual role for NTF4 in breast cancer which contributes to early metastasis of the disease. Therefore, NTF4 may serve as a prognostic marker and a potential therapeutic target for breast cancer.

Audience Take Away Notes:

  • Help the audience understand the multiple roles played by genes in the development of cancer
  • Can the audience translate the complex effects of these genes into clinical practice in conjunction with their own work
  • Help the audience understand the role and mechanism of these genes in cancer



Dr. Sun studied Oncology at the Chongqing Medical University, and graduated as PhD in 2019. She then joined the research group of Prof. Xiang at Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital. After three year postdoctoral fellowship supervised by Prof. Xiang, she obtained the position of a Deputy chief physician. She has published more than 10 research articles in SCI (E) journals.