Abstract:
Hypoxia is an inherent characteristic feature of the tumor microenvironment of hepatocellular carcinoma (HCC). Hypoxia inducible factors (HIFs), which are in charge of hundres of genes transcription at least, play essential roles in hypoxia-iinduced HCC progression. Increasing evidence have indicated that HIF-targetig genes play crucial roles in HCC progression, while the mechanisms are largely unknown. Here I will present a summary of what we have done about hypoxic microenvironment in HCC, as well as the newly discoveries.
Audience Take Away Notes:
- Hypxia induces HCC progression through diverse mechanism
- Some of the HIF targeting genes, such as PADI4, involve HIF transcriptial activity through positive feedback loops
- Kinds of HIF target genes have been identified, which promotes the research development progrsssion of hypoxia-related anti-tcancer drugs
