HYBRID EVENT: You can participate in person at Baltimore, Maryland, USA or Virtually from your home or work.
Yufeng Wang, Speaker at Oncology Conferences
Xian Jiaotong University, China


Hypoxia is an inherent characteristic feature of the tumor microenvironment of hepatocellular carcinoma (HCC). Hypoxia inducible factors (HIFs), which are in charge of hundres of genes transcription at least, play essential roles in hypoxia-iinduced HCC progression. Increasing evidence have indicated that HIF-targetig genes play crucial roles in HCC progression, while the mechanisms are largely unknown. Here I will present a summary of what we have done about hypoxic microenvironment in HCC, as well as the newly discoveries.

Audience Take Away Notes:

  • Hypxia induces HCC progression through diverse mechanism
  • Some of the HIF targeting genes, such as PADI4, involve HIF transcriptial activity through positive feedback loops
  • Kinds of HIF target genes have been identified, which promotes the research development progrsssion of hypoxia-related anti-tcancer drugs


Dr. Yufeng Wang studied clinical medicine at the Xi’an jiaotong university Health Science Center, China and graduated as MS degree in 2016. He received his PhD degree in 2020 at the same institution. Addition, he also worked as a visiting scholar for two years supervised by Dr Semenza at Johns Hopkins university School of Medicine. He then joined the First Affiliated Hospital of Xi’an jiaotong university as a hepatobiliary surgeon. He has published more than 50 research articles in SCI journals.