Abstract:
Squamous cell carcinoma is the most common tumor of oral cavity. The outcome of the Patient’s treatment depends not only on the stage but also on various prognostic parameters. They are: Stage grouping, Extra nodal spread, Depth of invasion, PNI, Worst pattern of invasion, Margin status etc. It was found in various studies that early-stage oral cancer doesn’t always portend good prognosis. Brandwein–Gensler et al, Jakobsson et al, Anneroth et al, Bryne et al, proposed a multiparametric histologic risk assessment score (HRS) that was reported to predict the survival of patients with T1 to T4 oral SCC and capable of differentiating high-risk and low-risk patients. Thus, early stage may require aggressive treatment if there are risk of adverse outcome present. The eighth edition of AJCC has recommended various changes in calculating the risk assessment. Depth of invasion (DOI) has been added as a modification to T to enhance the distinction between the superficial or exophytic tumors and those that are more invasive. Worst pattern of invasion (WOPI) plays an important role in the local regional recurrence. The presence of perineural invasion (PNI) is associated with poor local disease control, regional control, metastasis to regional lymph nodes and decrease survival. Lymph node involvement is the single most important prognostic factor.
This study was done in Pushpadi cancer care centre, Kota. Only patients of carcinoma oral cavity, who had undergone surgery and followed up for at least 3 years were taken. Total 100 patients were selected. The association of documented prognostic factors and recurrence of the disease were analyzed.
