Abstract:
Plasmablastic lymphoma is considered as not only as rarest entity as well as one of the most aggressive subtype of diffuse large B-cell lymphoma, which is mostly associated with immunocompromised states, but some cases also reported in immunocompetent patients. As we have in our case of 50-year-old immunocompetent female presenting with Plasmablastic lymphoma; initially manifesting as a rapidly enlarging breast mass with neurological manifestations of seizures. It posed a diagnostic dilemma because it shared features with plasma cell myeloma and extensive bone marrow involvement by plasma cell. This report emphasizes the importance of a multidisciplinary approach integrating histopathology, imaging, and clinical correlation to establish diagnosis and guide treatment. She was started on anthracycline base regimen with dexamethasone with addition of denosumab for hypercalcemia. She developed neutropenic septic shock and pneumonia after first cycle of chemotherapy and line sepsis with febrile neutropenia after second cycle of chemotherapy because of immunosuppression state and recovered with timely aggressive management but her primary disease is responding well with the treatment with close monitoring of treatment plus disease associated toxicity.
