Title : Meta analysis and model simulation of effect of nutraceuticals on fasting blood glucose in type II diabetic patients
Abstract:
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by high blood glucose levels resulting from defects in insulin secretion. A systemic review and meta analysis was conducted to determine effect of well known natural food supplements consumption on markers of glycemic control and lipid profile in T2DM patients. A systemic literature search using PubMed, Scopus and Web of Science yielded a total of 153 random controlled trial (RCT) reports belong to 29 active ingredients were included in the study, with 9284 T2DM patients divided into 4877 in the intervention group and 4407 in the placebo group.
RCTs reporting sufficient amount of data including the baseline and endpoint values or net changes between the two points for the intervention and control groups for T2DM disease were chosen. The meta-analysis revealed that saffron consumption significantly affected glycemic indices like FBG, glycated haemoglobin (HbA1c), and lipid profile indices like total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDLc), and high-density lipoprotein cholesterol (HDLc) levels when compared to controls and other supplements.
Several mathematical models have been used in studying the effect of drugs on T2DM. Of the several mathematical models available, a model developed by Dalla Man et al which is approved by Food and Drug Administration (FDA) was used to simulate the effect of nutraceuticals on FBG T2DM patients to match the meta-data.
Audience Takeaway:
- The meta-analysis result may show either a benefit or a lack of benefit of a treatment strategy, as indicated by the effect size, which is the phrase used to define an intervention's treatment effect. The treatment effect is the difference between the experimental and control groups in terms of gain (or loss).
- Audience can think of more sustainable solutions to the pandemic disease (diabetes) which is ruining the county’s wealth.
- This research could be adopted by any other faculty in their research or teaching.
- This meta analysis is a comprehensive search that includes 153 clinical trial outcomes and gives a full review of each dietary supplements effects on diabetes.
- This analysis would give new insights into the diabetes treatment strategies to reduce the regular drug dosage on daily basis.
- Researchers can use meta-analysis to merge smaller studies into one large study, which may assist reveal an effect. A meta-analysis can also help to improve the accuracy of the results. This is also because it effectively expands the scope of the investigation.
- List all other benefits.
