Hamzullah Khan

Title : Peripheral hematological predictors of morphological remission/hemopoitic recovery in plasma cell disorders after induction chemotherapy

Abstract:

Objectives: to determine the predictive values of peripheral hematological markers for remission in cases of Plasma cell disorders/Multiple myeloma after induction therapy.

Material and methods:This prospective study was conducted in the department of Hematology, MTI Hayatabad Medical Complex, Peshawar. All cases of Plasma cell disorders referred to department for remission after taking induction therapy, irrespective of age and gender were included. Relevant information’s were collected on a predesigned proforma prepared in accordance with the objectives of the study.

Result: A total of 36 cases referred for remission of plasma cell disorders were included, with 21(58.33%) were males and 15 (41.66%) females. The mean with standard deviation of numerical variables were; Age (56+ 8 years), Hb% (11+ 2.3 g/dl), Reticulocyte count (0.9+ 0.5% ) and plasma cells in the remission cases as 16+ 2.76%. Median of the TLC and Platelets in remission cases were 6275/cmm³ and 198000/cmm³ respectively. There was a significant association of remission with male gender (p=0.05) while no such association was seen in age groups (p=0.57). We observed a statistically significant an inverse correlation of remission (plasma cell in the bone marrow aspirations) with an increase in Hb% and retic count (r_s = -0.451, p = 0.006) and (r_s = -0.397, p = 0.053) respectively. A similar inverse correlation was seen between remission (plasma cell percentage) with TLC and platelet count that was not statistically significant(p >0.05). Hb% and Reticulocyte count showed a higher clinical sensitivity for remission with an Area Under Curve (AUC) of 0.733 and 0.736 on Receiver Operating Curve (ROC).

Conclusion: In cases of Plasma cell disorders with post-induction therapy, the peripheral blood values for an increased in Retic and Hb% predict the remission with 95% confidence. Remission favors male gender more as compared to female gender in all age categories.

Biography:

Dr Hamzullah khan is currently working as Professor of Haematology, Head Department of  Pathology& Director Research & Development Nowshera Medical College, MTI Nowshera lo

He has special interest in Research in Public Health, Haematology and infectious diseases. He has published more than fifty (80) Research articles in different national and international indexed journals. He has presented his research on various national and international forums.

He is also the incharge of the Blood bank and transfusion medicine. He has published more than a dozen research papers in current pandemic covering the prevalence, incidence, gender and age impact, morbidity, mortality of COVID-19.