Title : Clinical management of sickle cell disease
Abstract:
A brief background of disease: epidemiology, genetics, pathophysiology, clinical symptoms and complications. How disease is transmitted, changes in haemoglobin structure and function; how that affects patient health and organ function. Chronic and acute pain and how that affects patients’ life and surrounding environment; cardiovascular, respiratory, kidney/urinary tract, bone, skin and infectious clinical and laboratory presentation. Pain control management, with hydration, analgesia; therapeutic approach, prophylaxis of complications with hydroxyurea, antibiotics, vaccines, vitamin supplements; treatment of specific organ complications; precaution in pregnancy and surgical operations. Current strategies of cure with bone marrow transplant and gene therapy; future aspects.