HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

2nd Edition of International Summit on Hematology and Blood Disorders

June 05-07, 2025

June 05 -07, 2025 | Rome, Italy
Hematology 2025

Prevalence of thalassemia and hemoglobinopathy in eastern India A 10-year high-performance liquid chromatography study of 119,336 cases

Santosh Kumar Mondal, Speaker at Hematology Conferences
Department of Pathology and Laboratory Medicine AIIMS, India
Title : Prevalence of thalassemia and hemoglobinopathy in eastern India A 10-year high-performance liquid chromatography study of 119,336 cases

Abstract:

Background: Hereditary hemoglobin (Hb) disorders are the most commonly encountered single gene disorders in India. Proper timely identification of these disorders is of paramount importance to prevent thalassemia major and clinically severe hemoglobinopathy as well as for epidemiologic purposes.

Aims: Our aim was to determine the prevalence of thalassemia and hemoglobinopathy in patients of a tertiary care hospital of West Bengal, India.

Materials and Methods: This prospective study was conducted on 119,336 cases over a period of 10 years. After taking clinical history and familial history, complete hemogram report was obtained by an automated cell counter. Highperformance liquid chromatography (HPLC) was performed on the samples with Bio-Rad Variant using beta thalassemia short program. Confirmatory tests were performed whenever required.

Results: A normal Hb pattern was observed in 104,804 (87.83%) cases and abnormalities were detected in 14,532 (12.17%) patients. β (beta) thalassemia trait was the commonest abnormality found in 5,488 (4.60%) patients. HbE trait was found in 3,604 (3.02%) patients, β thalassemia major/intermedia in 1,981 (1.66%) cases, and Eβ thalassemia in 1,384 (1.16 %) cases. Other variants detected included HbE disease, sickle-cell disease, sickle β thalassemia, HbD-Punjab trait, HbQ-India trait, α-thal trait, double heterozygous state of HbS and HbE, double heterozygous state of HbS and HbD, HbJ-Meerut, hereditary persistence of fetal hemoglobin (HPFH), HbH, delta β-thal trait, and Hb Lepore.

Conclusion: In view of the high prevalence of hemoglobinopathy in this region, a routine premarital screening program is needed for the identification and prevention of high-risk marriages and thus, prevention of the psychosocial trauma of bearing a transfusion-dependent child for life.

Biography:

Santosh Kumar Mondal is a medical teacher for more than 21 years and my students includes from MD (Pathology), MDS, MBBS, B.sc (Nursing), BSc MLT etc. Now, he is working as the Professor, Department of Pathology & laboratory Medicine at AIIMS, Kalyani. He actively engaged patient care services/ hospital works as well as academics and medical research. At present, he has 82 publications with 1616 Google scholar citations. Besides, there are many administrative responsibilities in the Department of Pathology. As the nature of our work is a proper team work in most of the time, so one needs to know how to work in a group. He think he easily gel well with his colleagues, juniors and other staffs. At the same time, he carry on the instructions given to him by the competent authority. His aim to join this premiere institute is to become a good medical teacher, sincere hospital worker and dedicated academician/researcher.

Watsapp