Abstract:
Diagnostic monitoring of different states of the Immune system can be done by high throughput imaging of cell morphology or single cell molecular profiling. The relative abundances of cell types across donors highlights the heterogeneity of PBMC samples, even among healthy donors. This is particularly evident for rare cell types. Data on Systemic Auto-Inflammatory conditions was generated by the EU-funded ImmunAID consortium (grant agreement 779295). Our Multi-OMICS PBMC data is expanded by morphological characterization of PBMC’s using Deepcell technology. We have applied AI to count and sort various blood-based cell types in healthy and diseased conditions for studying cancer, transplantation rejection, Clonal Haematopoiesis of Indeterminate Potential.
Biography:
Dr. Peter J. van der Spek studied Genetics at the Erasmus University of Rotterdam, The Netherlands and received his PhD degree in 1996. He then joined the Osaka University research group of Prof. Fumio Hanaoka and worked with Tokyo University RIKEN institutes on cancer predisposition. He joined Akzo-Nobel/N.V. Organon in 1997 till 2000. Then he headed moved to Belgium to initiate bioinformatics activities at Janssen Pharmaceutica with Dr. Paul Janssen as part of the Johnson & Johnson family of companies. He received the JNJ Scientific Research Fellow award in 2003. Since 2004 Professor van der Spek is appointed by the Erasmus University Rotterdam. He runs a bioinformatics research line at Erasmus MC focusing on Personalized Healthcare and innovative, multi-omics big data producing molecular diagnostic techniques. Professor van der Spek has an h-factor of 70 and 247 published research articles in SCI (E) journals.
