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Ruchika Bajaj, Speaker at Pharmaceutics Conferences
University of California, United States
Title : Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein


P-glycoprotein (P-gp) plays a critical role in drug oral bioavailability and modulation of this transporter can alter the safety and/or e?cacy pro?le of substrate drugs. Individual oral molecular excipients that inhibit P-gp function have been considered as a mechanism for improving drug absorption, but a systematic evaluation of the interaction of excipients with P-gp is critical for informed selection of optimal formulations of proprietary and generic drug products. A library of 123 oral molecular excipients was screened for their ability to inhibit P-gp in two orthogonal cell-based assays. b-Cyclodextrin and Light green SF yellowish were identi?ed as modest inhibitors of P- gp with IC50 values of 168 mM (95% CI, 118-251 mM) and 204 mM (95% CI, 5.9-1745 mM), respectively. The lack of e?ect of most of the tested excipients on P-gp transport provides a wide selection of excipients for inclusion in oral formulations with minimal risk of in?uencing the oral bioavailability of P-gp substrates.


She has BSc (H) Biochemistry from University of Delhi and MSc. Biotechnology from Indian Institute of Technology Roorkee, India and received her PhD from Purdue University where she was trained as a Membrane Protein Biologist. Afterwards, she pursued her postdoctoral training at UCSF. She focused on ABC transporters all the way in her scientific training. She is very much passionate in elucidating in mechanistic underpinning of ABC transporter function using biochemical, biophysical and structural biology approaches, which could help to rationally design novel pharmacological tools to modulate the function of membrane proteins altered in disease.