Title : Synergism in the permeability of the blood-brain barrier of heavy elements under the influence of electromagnetic fields.
Abstract:
The possible effects of electro magnetic fields (EMF) in the human body are explained because the external EMF, as a physic toxic agent, induced to a possible physiological and biochemical molecular effects as in the electron transfer chain in the mitochondria, synthesis by ATP-synthase, electrochemical nervous transmission, muscular contraction, cardiac myocytes electric transmission, encephalic electric
transmission and other numerous electron fluxes. All of them induces to pathologies and individual hypersensitivities. It can take place releasing metal ions from numerous enzymes and metalloproteins, the 80 % of the proteins in the human body. After Einstein there is an interrelationship between mass, energy and movement.
A solenoid chamber of EMF is calibrated to exposure to 50 Hz. Determination of enzymatic activities of the electron transport chain complexes in brain of BALB/c mice exposed to a magnetic field of 50 Hz and 27.5 Gauss (2.750 mTeslas) during 1 to 4 Weeks. Experiments are performed in extracts of dissected cerebral regions hypothalamus and thalamus, and determined by spectrophotometry through kinetic colorimetric reactions.
The brain structures analyzed thalamus and hypothalamus of exposed mice 50 Hz, 2.75 mT shown a time-effect relationship at the 3rd Week. There appear marked individual higher responses for the activities of the two cytochromes (Complexes III and IV) in comparison to the control animals. This fact could show the existence of the hypersensitivity for certain animals, because only certain animals shown very high enzyme activities.
The European Parliament counselled to study the possible effects of the concurrence of chemical agents with electromagnetic fields in biomedicine. In the determination of biological effects of EMF in concurrence to environmental pollutants (heavy metals: Cd, Pb, Hg and others), show a synergism between magnetic field 0-300 MHz with Cd, Hg and Pb overload on the permeability of the blood brain barrier (BBB) and other physiological Systems. Toxic metals together with ELF-MF in mice induce to a synergism to the passage of neutral red dye to the brain. Hg, Cd and Pb induce a higher permeability to the BBB than magnetic fields. ELF-MF and heavy metals together have a synergism in the permeability of the BBB to the neutral red dye. Heavy metal ions have an affinity to the enzymatic thiolic groups. As before ELF-MF induce to vibrations and to the release of metallic ions from the enzymatic and protein molecules, bound by thyolic groups.
