Title : Taste Masking of Pediatric Formulation Using HME
Abstract:
Present study aims to utilize low temperature hot melt extrusion (HME) as a novel technology to mask bitter taste and also to develop a flexible and palatable solid oral dosage form to improve patient compliance. Pediatric patients need different oral dosage forms than adults due to differences in swallowing capabilities, taste likings, and dosage requirement. A manipulation in adult dosage form is often required to make it suitable and acceptable by pediatric patients. There are certain requirements and issues while administering existing pediatric dosage forms like requirement of dose measuring devices, chances of incorrect dosing, shaking requirement for dose accuracy in liquid dosage form and capability to administer whole quantity of formulation, chances of chewing and choking, limited dose flexibility, taste masking requirements, less stability of dosage form which instigate parents to do the manipulations.
So, there is a need to develop ready to take palatable and flexible solid formulation for children through oral route which do not require manipulations while administration and must be extremely pleasant and easy to administer.
