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Ujjwala Y Kandekar, Speaker at Pharma Conferences
JSPMs Rajarshi Shahu College of Pharmacy and Research, India
Title : Flaxseed mucilage/HPMC and sodium alginate/polyvinyl alcohol composite bilayer film as a promising drug carrier for periodontal treatment


The present study focused on the formulation of mucoadhesive bilayer composite films for the treatment of periodontitis and the evaluation of its physicochemical properties. The primary layer was prepared by flaxseed and HPMC composite to sustain the release of doxycycline hyclate. The second layer is comprised of sodium alginate and PVA composite for faster release of clove oil. Bilayer film was prepared by casting the second layer on the primary layer. ATR-FTIR results showed the intactness of drug and clove oil in the presence of excipients. The pH of the films was found to be compatible with periodontal cavity and the thickness of the film was suitable to insert in periodontal cavity. The immediate release layer showed faster disintegration and swelling. The content of clove oil was above 80%. The rate of swelling of primary layer was found slow and drug content complies with the United States Pharmacopoeia. SEM analysis revealed intact, non-porous and smooth films. The films exhibited better mechanical strength and bio-adhesiveness. Clove oil was released from the immediate release layer within 10 min. and doxycycline hyclate release was retarded minimum up to 8 h in primary layer as well as bilayer. The formulation also showed a significant effect on both E-coli and S. aureus. The prepared bilayer formulation can be effectively used for the treatment of periodontitis.

Audience Take Away Notes:

  • Periodontal diseases are the most spreading clinical condition all over the globe. Current research work was aimed to develop the targeted therapy for the treatment of periodontitis. By targeting to the periodontal area, the side effect associated with the oral treatment will be eliminated, and more specific targeting will be achieved along with a reduction in dose.
  • Other faculties have the scope to explore other drugs and polymers to target the periodontal cavity. The audience will understand the formulation and evaluation aspects regarding the preparation of periodontal film and they can proceed with research in a similar line. If this research work is explored further for in-vivo testing grants can be fetched to carry out research work.


Ujjwala Y. Kandekar graduated from Sinhgad College of Pharmacy, Pune, Maharashtra, India. She had completed her post-graduation from Dr. D. Y. Patil Institute of Pharmaceutical Education and Research, Pune, Maharashtra, India. Then she joined Jawaharlal Nehru Technological University, Anantapur, Anantapuramu, Andhra Pradesh, India in 2017. Currently, she is working as Associate Professor at JSPM’S Rajarshi Shahu College of Pharmacy, Pune, Maharashtra, India. She had contributed in two book chapters published by CRC press and published 14 research papers and presented 9 posters at various conferences.