Title : Hot melt extrusion technique: A solution for poorly soluble drugs
Abstract:
One of the novel advanced techniques established for enhancement of the dissolution rate and bioavailability, controlling or modifying drug release, taste masking, and stabilizing the active pharmaceutical ingredient (API) is Hot melt extrusion (HME). A combination of Drugs, polymers and plasticizers make up part of the formulation ingredients. During the extrusion process, thermal binders can be used. Enhancement of dissolution and further animal study is of importance. One such case study reveals the dissolution enhancement.
Audience Take Away Notes:
- HME techniques provides several advantages with major advantage of taste masking for bitter drugs and are acceptable by all age group people.
- Yes the concept of poor solubility of drug has gained vast acceptability in several areas of research and so understanding the concept and making it aware by the faculty is of importance.
