Luis Jesus Villarreal Gomez

Title : Mucoadhesive electrospun fibrous systems for the fast and sustained delivery of drugs

Abstract:

The necessity of new systems for drug delivery in children and specific procedures is clearly needed, in the case of children the difficulty of the correct dose administration is a problem when the drug carrier is not easy to administrate by a non-specialized adult. Mucoadhesive electrospun fibrous systems are an interesting alternative for the treatment of pathologies in the oral cavity due to their capacity to release pharmaceutical drugs at a fast and sustained rate.  Electrospun fibers have many characteristics that make them ideal drug carriers for local delivery. Mucoadhesives fibrous systems of poly (vinyl alcohol) and poly (vinyl pyrrolidone) loaded with propranolol and dexamethasone phosphate will be discussed for their potential application in the oral cavity. Physicochemical (SEM, FTIR, TGA, DSC) and biological (MTT assay) characterization will be described in order to present the morphology, chemical composition, and thermal behavior of the fibrous mats, and cytotoxicity in fibroblast will be visualized, drug delivery rate, mucoadhesive and degradation rate will be also discussed. The evaluated mucoadhesive loaded fibers presented potential characteristics to be used in the oral cavity, where successfully tridimensional fibrous scaffolds were fabricated with an average fiber diameter of about 368 ± 161 nm, thermal stability higher than 250oC, fibers were degraded completely before 15 min and high mucoadhesive and biocompatibility in fibroblast were observed. All these results give potential characteristics to these systems and promote the continuing evaluation at higher levels such as in animals and clinical studies. Poly (vinyl pyrrolidone) loaded fibers with dexamethasone phosphate are proposed for endodontic procedures avoiding injection of the anti-inflammatory drug and poly (vinyl alcohol) loaded fibers with propranolol for the treatment of hemangiomas in children.

Audience Take Away Notes:

• Innovation in mucoadhesive systems
• Applications of the electrospinning technique
• Innovation in drug delivery administrations

Biography:

Dr. Luis Jesus Villarreal Gomez, studied Chemistry-Biology at the University of Sonora, Hermosillo, Mexico and graduated in 2004. He then received his PhD degree in 2013 at the University Autonomous of Baja California, Tijuana, Mexico where he joined as full research professor. Dr. Villarreal is founder and editor in chief of the Revista de Ciencias Tecnologicas (RECIT) (ISSN 2594-1925) and is editorial board member of several journals edited from MDPI, Hindawi, BenthamOpen, amongst others. Until now, he been published 32 papers and have been reviewed more than 120 reviews. His research lines are biomaterials, tissue engineering, drug delivery systems and biotechnology.