Aqueous dispersions of organogel nanoparticles and porous materials as water insoluble drug delivery systems

Title : Aqueous dispersions of organogel nanoparticles and porous materials as water insoluble drug delivery systems

Abstract:

Organogels are semi-solid systems, in which an organic liquid phase is immobilized by a three-dimensional network. The self-organization of low molecular mass organic gelator by non-covalent interactions form fibrous structures responsible for the gelation process. The organogels were made up of an oil and 12-hydroxystearic acid (HSA). Because of their low toxicity and biocompatibility, organogels are very attractive as biomaterials. We characterized them by different techniques and developed original systems for biomedical applications. This work concerns the use of colloidal dispersions or porous materials based on organogel as drug delivery system. Gelled oil nanoparticles systems as vehicles for drug delivery are an alternative to emulsions or Solid Lipids Nanoparticles (SLN). Such organogel nanoparticles are interesting for the delivery of water-insoluble drugs. The preparation process of the gelled oil nanoparticles is obtained by hot emulsification (T°>Tgel), leading to a stable semi-solid dispersion after cooling (T°<Tgel). Different dispersions of organogel particles were prepared, leading to a large range of interesting textures, from liquid dispersions to structured gels¹. These results enable the understanding of the mechanisms leading to different particles organizations, and thus a control on the texture appearance of the systems through formulation. We evaluated the encapsulation properties and delivery of nanoparticles dispersions using different drugs and models, varying their hydrophobicity and pKa². Microporous organogel were also investigated as biomaterial for probiotic delivery. In this case, we focused on the design of soft materials based on microporous organogels matrices. Particulate leaching technique with predesigned leachable sugar and salt templates was used for controlled porosity introduction into the basic organogel materials³. The results demonstrate that the obtained microporous organogels with an appropriate porosity and microarchitecture can be used as artificial extracellular matrices for probiotic absorption.

Biography:

Sophie Franceschi has her expertise in chemical and physicochemical studies of organized molecular systems for drug delivery and material applications. She has twenty years of experience in research and teaching. She is graduated with a PhD from the Paul Sabatier University of Toulouse (France). in 1997 and has a master’s degrees in Molecular and Supramolecular Chemistry. Currently, she is researcher in SMODD group in the IMRCP laboratory at the University Paul Sabatier of Toulouse and also teacher at Paul Sabatier University. She is teacher responsible of the formulation in MASTER at the University.