Title : Enhancing solubility of poorly water soluble drugs by micellization with the help of Non-ionic carbohydrate based gemini surfactants
Abstract:
Micelles formed by surfactants can be used for selective solubilisation and reactions which exploit their nanometre size and mimic the membranous biological system i. e. carbohydrate derived non-ionic surfactants are typically employed to increase solubility of poorly water soluble drugs. Novel carbohydrate derived surfactants with varying tail lengths of 12, 14 and 16 carbons have been synthesized in our laboratory. The structure and purity of these surfactants were confirmed using elemental analysis, ESI mass spectrometry and 1H and 13C NMR spectroscopy. These amphiphiles were explored as micellization systems for encapsulation of poorly water soluble drugs viz. Glibenclamide, Clofibrate and Norfloxacin in order to increase their water solubility and thus their bioavailability. Micellar studies revealed that these carbohydrate derived surfactants encapsulated drugs in the sequence Clofibrate > Norfloxacin > Glibenclamide. In all cases, aqueous solubility increased with increase in chain length of the surfactant.
Key Words: Micelles, glucose, non-ionic surfactants, poorly soluble drugs, encapsulation, epoxide