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Nirmal Singh, Speaker at Pharma Conferences
RSD College Ferozepur, India
Title : Enhancing solubility of poorly water soluble drugs by micellization with the help of Non-ionic carbohydrate based gemini surfactants

Abstract:

Micelles formed by surfactants can be used for selective solubilisation and reactions which exploit their nanometre size and mimic the membranous biological system i. e. carbohydrate derived non-ionic surfactants are typically employed to increase solubility of poorly water soluble drugs. Novel carbohydrate derived surfactants with varying tail lengths of 12, 14 and 16 carbons have been synthesized in our laboratory. The structure and purity of these surfactants were confirmed using elemental analysis, ESI mass spectrometry and 1H and 13C NMR spectroscopy. These amphiphiles were explored as micellization systems for encapsulation of poorly water soluble drugs viz. Glibenclamide, Clofibrate and Norfloxacin in order to increase their water solubility and thus their bioavailability. Micellar studies revealed that these carbohydrate derived surfactants encapsulated drugs in the sequence Clofibrate > Norfloxacin > Glibenclamide. In all cases, aqueous solubility increased with increase in chain length of the surfactant.

Key Words: Micelles, glucose, non-ionic surfactants, poorly soluble drugs, encapsulation, epoxide 

Biography:

Dr. Nirmal Singh Studied in the Department of Applied Chemistry, Specialized in Pharmaceutical science at Guru Nanak Dev University, Amritsar in 1999. He then joined Ph.D. at IKG Punjab Technical University, Kapurthala (Punjab) received his PhD degree in 2015 at the same institution in Organic Chemistry. He qualified UGC – NET examination with All India Rank 11 and also qualified for GATE. He has published more than 45 publications including 14 research articles in SCI(E) journals.
 

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