Scallop male gonad powders improve exercise performance and exert antifatigue effect via alleviating the oxidative stress and modulating inflammatory cytokines in mice

Title : Scallop male gonad powders improve exercise performance and exert antifatigue effect via alleviating the oxidative stress and modulating inflammatory cytokines in mice

Abstract:

Scallop male gonad (SMG) is the primary edible by-product of scallop P. yessoensis during scallop adductor muscle processing. In this work, SMG powders at the dosage of 50 mg/kg/d, 100 mg/kg/d, and 200 mg/kg/d were supplied in male ICR mice. SMG powders showed comparable anti-fatigue effect with positive controls of whey and soy isolate proteins. In detail, SMG powders increased the exhausted swimming time of mice by 1.4-1.8 folds, and increased the content in glucose, liver glycogen, and muscle glycogen by 1.1-1.9 folds in a dosage-dependent behavior compared to the Con-S group. Meanwhile, SMG powders could maintain the muscle tissue with orderly arrangement morphology after acute vigorous exercise. Moreover, compared with Con-S group, the SMG powders alleviated the oxidative stress, reflected by down regulation of NAD+/NADH in muscle tissue, and increasing APT content in muscle tissue by 1.2 folds , SOD content in serum by 1.1 folds. In addition, protein and amino acids decomposition could be alleviated reflected by 14%-22% decline in BUN as SMG powders increasing. The decreased accumulation of BLA by 10%-12% in SMG-treated group corresponded well with the down regulation in LDH by 11%-20% in serum. Besides, SMG powders down regulated the pro-inflammatory cytokines levels of IL-1β and IL-6 by 35% and 46% decline compared with Con-S group at the high dosage. The effective anti-fatigue activity of SMG could be associated with high antioxidant-related amino acids contents of 25.76% and branched-chain amino acids contents of 14.61%, promising the development of food administration to increase exercise tolerance.
Audience Take Away: 

• SMG powders showed effective anti-fatigue ability in a dose-dependent behavior.
• SMG powders significantly prolonged the exhaustive swimming time in mice.
• SMG powders promoted energy substance production in mice during exhaustive swimming.
• SMG powders decreased BLA accumulation corresponding to decreasing LDH levels.
• SMG alleviated fatigue by regulating oxidative stress and inflammatory responses.Explain how the audience will be able to use what they learn?

Biography:

Dr. Jianan Yan has completed his/her PhD at the age of 30 years from Dalian Polytechnic University, China. She has over 20 publications in national and international journals as the first or corresponding author.