Title : The emerging role of induced pluripotent stem cells and its derivatives in periodontal regeneration: A scoping review of preclinical studies
Abstract:
The main goal of periodontal regenerative therapy is to regenerate fully functional tissues that can replace the deteriorated ones resulted from periodontitis and injuries. Tissue engineering methods provide promising results in periodontium reconstruction and within its developments, induced Pluripotent Stem Cells (iPSCs) present a reliable candidate cell source for this goal. This review aimed to assess preclinical studies regarding the iPSCs’ potential in inducing regeneration of periodontium. Studies that evaluated direct or indirect impact of iPSCs in differentiation to periodontal-related tissues were included. Among 10 included studies, 8 studies had both invitro and in vivo parts. Growth/differentiation factor-5 and enamel matrix derivative were the most used signaling molecules, followed by bone morphogenic protein-2 and metformin. In most of the studies, positive outcomes regarding vascularization, bone formation and periodontal-related markers’ expression were reported. Use of iPSCs and its derivatives may lead to a novel tissue engineering platform in for periodontal regeneration.
