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ICC 2019

Zhenlong Ye

Zhenlong Ye, Speaker at Cancer Events
Shanghai Baize Medical Laboratory, China
Title : Application of CTCs for biomarker development of immunotherapies


I mmunotherapies with chimeric antigen receptor-modified T (CAR-T) cells and Immune Checkpoint Inhibitors (ICIs) have shown exhilarative clinical outcome in treating Cancers. When applying CAR-T-based and ICIs-based immunotherapies for treating solid tumors, detection of expressions of targeting antigens on tumor tissues with IHC assays is required. For example, MSLN and PD-L1 detection with IHC assays for MSLN-CAR-T-based and PD1-based immunotherapies, respectively. However, assays on tumor tissue specimens can be limited by age, quality, and resection of patients. Thus, CTCs collected from blood can be used for detection of expressions of targeted antigens on tumor cells, and the concentration of PD-L1 that has been used as biomarkers for PD-1-based immunotherapies. In our work, we explored and validated the application of CTCs as standard biomarker for CAR-T-based and PD-1-based immunotherapies. Mesothelin, EGFR, MUC1, MMR, and PD-L1 were analyzed in CTCs for relative CAR-T cell-based therapies. And DNA from CTCs can be used for ctDNA sequencing for TMB and targeted therapy tests.


Zhenlong Ye, Ph.D of Oncology, is the General Manager of Detection Department of Shanghai Cell Therapy Group Co., Ltd. He is also the member of Clinical Application Committee of Medicinal Biotechnology of China Medicinal Biotechnology Association and Vice-Chairman of Youth Science Group, and the member of Precision Medical Branch of China Medicinal Biotechnology Association. He has published 10 SCI papers as the first author or communication author, 15 patents as principle investigate and also participated in the compilation of one Chinese edition and one English edition. Besides, he is awarded the Shanghai Science and Technology Committee Rising-Star talent in 2019 and is the 12th batch of Shanghai Jiading District’s shortage of innovative and entrepreneurial talents, and the 15th Shanghai Youth Post Expert.