Abstract:
Nanomedicines are promising strategies for anticancer therapy; however, camouflaging nanomedicines with cell based carrier i.e. platelet membrane would significantly prolong its retention time in the bloodstream, enhance the targeting ability and reduce the off-target effects. Anticancer nanoparticles wrapped inside patient,s own platelet membrane shall act as mimics which contain the complete set of surface receptors, antigens and proteins naturally present on platelet membranes This technique takes advantage of the unique natural properties of human platelet membranes, which have a natural preference to bind to certain tissues and organisms in the body, this targeting ability, which red blood cell membranes do not have, makes platelet membranes extremely useful for targeted drug delivery.
Platelets have great prospective as drug delivery systems, proficient of causing extraordinary changes in pharmacokinetics, pharmacodynamics and immunogenicity. These were found ensuring better stability of the particles, better escape from reticuloendothelial system, biocompatible and non-toxic, hence not inducing immunological response. These particles evade immune system attack. The natural flexibility permits the platelet mimics to distort and travel through narrow capillaries. Attachment of some fluorescent materials based on FRET (Förster resonance energy transfer) makes the process of drug delivery more convenient to monitor . Our present work concerns preparation of human platelet membrane nanoparticles dispersed with anticancer drugs for oral cancer.In addition to using commercially available drugs ,we are using herbal bioactives and other small molecules designed through in silico studies.
