The hamartomatous polyposis syndromes are a heterogeneous group of rare syndromes showing autosomal dominant inheritance and characterized by the onset of gastrointestinal hamartomatous polyps and increased cancer risk. Among them there are the Peutz-Jeghers syndrome, juvenile po [....] » Read More
Breast papillary lesions exhibit broad range. Tajima et al. reported in discrimination between benign intraductal papilloma (IDP) and malignant endocrine ductal carcinoma in situ (E-DCIS), new marker of CD56 is useful for discriminating between benign and malignant. Relationship [....] » Read More
The protein diversity of mammalian cells is determined by arrays of isoforms from genes. Genetic mutation is essential in species evolution and cancer development. Accurate Long-read transcriptome sequencing at single-cell level is required to decipher the spectrum of protein exp [....] » Read More
Background: There are disparities in outcomes for Aboriginal children with acute leukaemia, with reduced enrolment onto clinical trials and increased rates of loss to follow-up. Inequalities can result from reduced access to health-care services due to remote living, cross-cultur [....] » Read More
Cancer Therapeutics-related Cardiac Disfunction (CTRCD) is a cardiovascular disease caused by cancer therapies. It is essential to detect CTRCD at an early stage to prolong patients’ lives. However, there aren’t any established screening tests other than ultrasound ca [....] » Read More
Protein disulfide isomerase A3 (PDIA3) is a kind of thiol oxidoreductase with a wide range of functions, and its expression is elevated in a variety of tumors, which is closely related to the invasion and metastasis of tumor cells, and has a significant impact on the immunogenic [....] » Read More
Background: China faces a disproportionate cancer burden to the population size and is undergoing a transition in the cancer spectrum. A comprehensive analysis of the current cancer profiles in China is still urgently needed to provide references for further formulation and adjus [....] » Read More
Background: In recent decades, various standardized classification systems for reporting cytopathology have been implemented, which have revolutionized the management of patients with cancerous and non-cancerous conditions by establishing effective communication between clinician [....] » Read More
Neuroblastoma is a rare neoplasm whose prognosis becomes poor as age advances. It is a tumour of neural crest cell origin, primarily occurring in abdomen. Due to its poor morbidity and poor survival, there is no standard protocol. We report three cases of Neuroblastoma which were [....] » Read More
Breast cancer (BC) is the most commonly diagnosed cancer in women in the world. Many studies have shown that phenolic acids are anticancer agents. 2,3-dihydroxybenzoic acid (2,3-DHBA) is a natural phenolic acid found in different fruits or vegetables. Lipidomic approaches investi [....] » Read More
Background: Thymoma comprises 20% of all mediastinal neoplasms and 50% of all primary tumours in the anterior compartment. Thymic surgery has undergone a paradigm shift in approach from being transcervical to Video assisted. Video assisted thymectomies in selected patients can de [....] » Read More
Breast cancer is a type of cancer that develops in the breast tissue. It is the most common cancer in women worldwide. Breast cancer developed silently without medical attention, and most cases are discovered during a routine clinic visit. Mortality rates of breast cancer getting [....] » Read More
Background: As a common and incurable cancer originating from plasma cells, multiple myeloma (MM) represents 10% of hematological cancers. Most cancer-related genes involved in MM development are currently unknown. Deletions in chromosome 8p23.1, harboring multiple candidate tumo [....] » Read More
Introduction: The tobacco epidemic is one of the biggest public health threats the world has ever faced, killing more than 8 million people a year, including around 1.2 million deaths from exposure to second-hand smoke. Every eight seconds someone, somewhere in the world, dies as [....] » Read More
Background: Head and neck cancer patients experience cachexia that causes weight loss, poor response to treatment, and decreased overall survival rates. The study aims to determine the prevalence of cachexia in head and neck cancer patients and analyze their laboratory parameters [....] » Read More
Introduction: Pancoast tumours, a subtype of non-small cell lung carcinoma (NSCLC) was an obscure entity until Henry Pancoast first described them in the 20th century. These tumours primarily involve the apical chest wall and thoracic inlet structures, and their diagnosis require [....] » Read More
This presentation will focus on the advancements made in cancer biomarkers. Cancer biomarkers can be important in identifying targeted treatment options and personalizing the cancer treatment based on the genomic profile of the tumor. Studies have been published that provide evid [....] » Read More
Melanoma is a highly aggressive skin cancer that frequently metastasizes, but current therapies only benefit some patients. Here, we demonstrate that the serine/threonine kinase cell division cycle 7 (CDC7) is overexpressed in melanoma, and patients with higher expression have sh [....] » Read More
Patients receiving treatment for cancer by any modality are likely to experience side effects that affect their ability or desire to consume a variety of nutritious foods. This is a critical issue as maintaining good nutrition and health during treatment may affect patient tolera [....] » Read More
Detecting cancers at the population level can dramatically reduce mortality rates, but there is no way to systematically detect all cancers today. Here we develop an accurate cancer detection system to discriminate multiple types of cancers by integr [....] » Read More
Introduction: Capecitabine is an oral prodrug of antimetabolite 5-fluorouracil (5-FU), used to treat metastatic breast and colorectal cancer. Variability in therapeutic levels of 5-FU and severe neurologic (e.g., hand-foot syndrome), gastrointestinal, and hepatic toxicities [....] » Read More
Breast cancer continues to be a difficult disease to treat due to high rates of metastasis. Metastasis to the brain presents a unique and often overlooked challenge. In this focused review, we discuss the epidemiology of breast cancer and which types frequently metastasize to the [....] » Read More
Creatv Bio provides innovative liquid biopsy blood tests for cancer screening, cancer prognosis and predicting cancer treatment response. We were the first to discover and research the clinical applications of tumor macrophage fusion cells found in the blood of cancer patients. T [....] » Read More
Background: The vast majority of male breast cancer (MBC) is treated with total mastectomy without reconstruction, while female breast cancer patients are commonly offered less deforming surgical procedures such as partial mastectomy, nipple-sparing mastectomy (NSM) and areolar-s [....] » Read More
Neoadjuvant chemotherapy (NACT) has been known to induce genomic and transcriptomic alterations within tumours. Here, using transcriptome profiling along with histological analysis of pre and post NACT tumours, we show temporal and disease site-specific differences (omentum, ovar [....] » Read More
Chromatin bridges are strings of chromatin connecting the anaphase poles or daughter nuclei and have been linked to tumourigenesis. In response to chromatin bridges in cytokinesis, eukaryotic cells delay abscission, the severing of the narrow cytoplasmic canal that connects the t [....] » Read More
Coronavirus disease 2019 (COVID-19), a respiratory illness caused by betacoronavirus SARS-CoV-2, has broad clinical presentations ranging from asymptomatic to fatal outcomes. Due to their immunocompromised status, cancer patients are at an increased risk for severe SARS-CoV-2 inf [....] » Read More
Polybromo-1 (PBRM1) is an epigenetic-related gene, and the loss of PBRM1 protein in tumor cells has been expected as a potential biomarker for clear cell renal cell carcinoma (ccRCC). Whereas there is little knowledge about how PBRM1 immunohistochemical expression correlates with [....] » Read More
Pancreatic ductal adenocarcinoma (PDAC) has a dismal patient prognosis with overall survival of merely ~10% mainly due to the lack of effective diagnostic and therapeutic measures. In PDAC, there have been identified high rates of alterations in the oncogene KRAS and the tumor su [....] » Read More
Objective: Para-aortic lymph node dissection (PALND) is a widely used treatment that causes many complications. This study is to evaluate the efficacy and safety of nerve-sparing para-aortic lymph node dissection (NSPALND) by comparing it with conventional PALND in gynecological [....] » Read More
Objective: Upper gastrointestinal cancer is one of the malignant tumours which seriously threaten human health. However, there are no multicentre studies evaluating the effectiveness of the endoscopic screening for upper gastrointestinal cancer in urban area. We aimed to estimate [....] » Read More
Nanomedicines are promising strategies for anticancer therapy; however, camouflaging nanomedicines with cell based carrier i.e. platelet membrane would significantly prolong its retention time in the bloodstream, enhance the targeting ability a [....] » Read More
Chronic Obstructive Pulmonary Disease (COPD) and Lung cancer are the major reasons for lung disease related mortality worldwide. Chronic inflammation is a key attribute of COPD and a potential driver of lung carcinogenesis. Among various environmental risk factors, cigarette smok [....] » Read More
Amongst the various treatment models, chemotherapy is the most significant and widely practiced to cure cancer. More computerized mathematical models have been introduced for controlling the growth of tumors and also to maintain normal and immune cells in their desired valu [....] » Read More
Renal cell carcinoma (RCC) is the most difficult-to-treat form of kidney cancer with a median 5-year survival of 10% under metastatic setting. Although cytoreductive nephrectomy is common, approximately 20–30% of patients will develop recurrent cancer after surgery, which h [....] » Read More
In this study Mg_(1-x) Co_x Fe_2 O_4 (0≤x≤1 with ?x=0.1) nanoparticles were synthesized by chemical co-precipitation method and annealed at 200oC, 400oC, 600oC, and 800oC in order to study their potential applications for hyperthermia therapy of cancer. The structural prope [....] » Read More
Cancer of oral cavity is commonest in india. Generally, patients come with locally advanced tongue cancer. The treatment for this cancer is multi-modality. For resectable cancer, multiple surgical approaches are described in the literature. Mandibulotomy for resection of the midd [....] » Read More
Blood cancer has become quite common in all age groups, worldwide. The cancer ranges from Acute life-threatening leukemias to indolent chronic leukemias, Lymphoma spillovers causing morbidity and mortality to slow-growing indolent lymphomas. Since blood is present everywhere in t [....] » Read More
Colorectal cancer (CRC) is one of the leading causes of cancer death in the world. Deregulation of cyclin- dependent kinases (CDKs) is often observed in CRC making them attractive drug targets. We investigated the efficacy of three multitarget CDK inhibitors viz. riviciclib (also [....] » Read More
Cancer cells are characterized by overhydrated state and contain more than 90% of water (Kircuita et al., 1973). Cell overhydration serves as one of the diagnostic parameters for carcinogenesis (Damadian 1971). However, the nature of metabolic mechanism, the dysfunction of which [....] » Read More
Breastfeeding is a highly accessible and low-cost public health measure. Several studies have shown the benefits of breastfeeding for the baby and the mother. Aspects such as strengthening the mother-child bond, adequate nutrition, and immunological protection were widely evaluat [....] » Read More
during the presentation, the role of exercise for oncology patients will be outlined. Within this context, established benefits and recommendations regarding exercise as a supportive treatment will be overviewed, as well as mechanistic insights. Additionally, preliminary evidence [....] » Read More
Glioblastoma multiforme (GBM) is considered the most aggressive brain malignancy associated with poor prognosis. MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression and have been found to play a role in GBM progression. MiRNAs can serve as promising diagnosti [....] » Read More
Chromatin bridges are strands of incompletely segregated DNA connecting the anaphase poles or daughter nuclei. If unresolved, chromatin bridges can break in cytokinesis leading to micronuclei formation and accumulation of DNA damage. To prevent this, human cells form accumulation [....] » Read More
Resonance phenomenon consists of the oscillation at high amplitude of a material if it is forced mechanically, acoustically or electrically at some specific frequencies named natural resonance frequencies. In particular, some researchers have hypothesized that biological systems [....] » Read More
DNA methylation is one of the most well-studied epigenetic regulation factors, which involved in almost all DNA metabolism pathways including gene expression, DNA replication, DNA damage repair, chromatin structure et al. Like genetic alterations, DNA methylation aberrancies comm [....] » Read More
Little is known about the potency of angiogenesis-associated genes (AAGs) in the regulation of the immune microenvironment of multiple myeloma (MM). Traditional Chinese medicine has positive anti-angiogenesis and immunomodulatory effects, especially in the treatment of tumors. Al [....] » Read More
A. Hit evolutionary hypothesis: Alphabetic code for cancer management, based on the comprehensive strategic network by considering single cell based analysis/pedigree platform/ Micro-,macro/environmental factors which have significant role through the pre- and post-embryonic per [....] » Read More
In clinical practice, it is also common to see tumor recurrence with distant metastasis in breast cancer patients after chemotherapy, which leads to increased mortality of breast cancer patients. Therefore, it is of great theoretical significance and practical clinical applicatio [....] » Read More
Esophageal cancer(EC) is a common digestive malignancy that ranks sixth in cancer deaths, with a 5-year survival rate of 15-25%. As a result, reliable prognostic biomarkers are required to accurately predict the prognosis of EC. T-cell exhaustion(TEX) is associated with poorer pr [....] » Read More
Objective: Dissecting the cellular/molecular/genetic regulatory biochemical signaling networks: Autophagy/Toll-like Receptors/Wnt-Frizzled in inflammatory “gastrohepatic disease-web” primarily hepatocellular/colorectal/cholangiocarcinomas is essential for diminishing [....] » Read More
The One Health Initiative integrates the interactions between the environment, animal and human health, which opened the doors to work in a multidisciplinary way and address problems from a more comprehensive perspective. The translational or comparative medicine contemplates the [....] » Read More
A case-based discussion will be done by me about PRES (posterior reversible encephalopathy syndrome). Firstly, I will discuss a case to help the audience to understand the disease with good understanding of how the syndrome presents then I will go through Clinical features, patho [....] » Read More
Title : Sensor technology for detection of biomarkers in gynecological medicine
Michael Thompson, University of Toronto, Canada
Detection of gynecological disorders of female reproductive organs, especially forms of cancer, typically involves screening of symptoms for the illnesses, followed by imaging with ultrasound or MRI. These techniques are time consuming and require trained professionals to perform [....] » Read More
Title : Revisiting the treatment of anemia in the setting of chronic kidney disease, hematologic malignancies, and cancer
Franco Musio, University of Virginia School of Medicine, United States
Anemia has and will continue to be a central theme in medicine particularly as clinicians are treating a burgeoning population of complex multiorgan processes. As a result of multiple randomized controlled trials (RCA), meta-analyses, and medical societal recommendations ove [....] » Read More
Title : Coordination of the cytomatrix micromechanics and the Warburg effect support survival of cancer cells
Tattym Shaiken, Baylor College of Medicine, United States
For decades cancer studies have focused on molecular genetics while the role of the cytoplasm has remained obscure. Separation of the viscous fluid cytosol and elastic-solid cytomatrix has offered an opportunity to solve an age-old mystery in biochemistry; how millions of complex [....] » Read More
Title : The daily availability of granulocyte transfusions in a large oncology center
Fleru M Aung, The University of Texas MD Anderson Cancer Center, United States
Introduction: Granulocyte transfusions are requested to treat severely neutropenic adult/pediatric Leukemic and Stem cell transplant patients with overwhelming bacterial/fungal infections. Clinical indications range from organ specific to soft tissue infections infection. Reques [....] » Read More
Title : Sinonasal undifferentiated carcinoma: A case report and brief literature review
Lashitha Reddy Konda, University of Buckingham, United Kingdom
Sinonasal undifferentiated carcinoma is a rare malignancy, of the nasal cavity and/ or paranasal sinuses accounting to be less than 1% of all malignancies. This case report will discuss a young male patient diagnosed with poorly differentiated carcinoma in the lateral wall o [....] » Read More
Title : Skeletal health in childhood cancer: A novel team approach to addressing a common late effect of cancer treatment
Michell Fullmer, Nemours Childrens Hospital, United States
Children with cancer are at an increased risk of developing osteonecrosis (ON) and decreased bone mineral density (BMD). In Acute Lymphoblastic Leukemia, patients aged 10 to 20 years are 10-20 times more likely to develop ON compared to younger children and adults. Al [....] » Read More
Title : Novel Siglec-15-Sia axis inhibitor leads to colorectal cancer cell death by targeting miR- 6715b-3p and oncogenes
Shoib Sarwar Siddiqui , University of Hertfordshire, United Kingdom
Colorectal cancer (CRC) has been referred to as the fourth most diagnosed cancer worldwide and the third leading cause of patient mortality in humans. Approximately, 1,931,590 new cases of CRC were reported with 935,137 patient deaths worldwide in 2020. CRC has become increasingl [....] » Read More
Title : The role of SRPK1 in tumour chemoresistance
Duygu Duzgun, University of Exeter, United Kingdom
Resistance to chemotherapeutic drugs is a major setback in cancer therapy, which leads to a high proportion of relapses and poor survival outcomes in cancer patients. Chemoresistance is frequently elicited by abnormal pre-mRNA alternative splicing, regulated by crucial kinases su [....] » Read More
Title : Gynecological sarcomas - the challenges of diagnosis and treatment
Lian Ulrich, Copenhagen University Hospital Rigshospitalet, Denmark
Sarcomas are rare gynaecological tumours, but because most have a bad prognosis, it is important to know when to suspect a sarcoma and to be able to diagnose it from the common uterine fibroleiomyomas. The most common variety of gynaecological sarcomas is the leiomyosarcoma, whic [....] » Read More
Title : Evolution of laparoscopic oncosurgeries in Rural Western India – our experience at a tertiary level 100 bedded private hospital over last 12 years
Akshay Kishore Nadkarni, 21st century hospitals Vapi, India
Laparoscopy has been a boon to mankind. Its first use has evolved during the 80’s & 90’s only for benign diseases. Over the years, it has evolved in complex cancer surgeries mainly abdominal & thorasic cancers. Last 10 years has seen the outcomes of minimally [....] » Read More
Title : Differentially expressed genes between wild type and drug resistant human cervical cancer cell lines
Nauf Bou Antoun, Kingston University, United Kingdom
Background: Cervical cancer although is highly preventable, is still the 4th most common cancer in women globally. World Health Organization estimate 640,000 new cases and 342,000 deaths in 2020, indicating the need for effective treatment at late stages of the disease, when it i [....] » Read More
Title : Laparoscopic radical hysterectomy – our experince in Rural South Gujarat India
Akshay Kishore Nadkarni, 21st century hospitals Vapi, India
Introduction: Laparoscopy has been a boon to mankind. Its first use has evolved during the 80’s & 90’s only for benign diseases. Over the years, it has evolved in complex cancer surgeries mainly abdominal & thorasic cancers. Last 10 years has seen the outcomes [....] » Read More
Title : A biomimetic nanoreactor for combined chemo/chemodynamic therapy on tumor through synergistic apoptosis and ferroptosis strategy
Hui Yu, Xi’an Jiaotong University, China
Chemotherapy is a traditional method in clinical cancer treatment. As a malignant solid tumor caused by abnormal proliferation of trophoblastic cells, choriocarcinoma can be cured by chemotherapy for preserving patients’ fertility potential. But at present the biggest hurdl [....] » Read More
Title : The global landscape of nasopharyngeal cancer incidence and mortality in 2020 and projections to 2040
Yanting Zhang, Guangdong Medical University, China
Background: Nasopharyngeal cancer (NPC) is one of the most common cancers in head and neck. Understanding the current epidemiological profile of international variations in NPC incidence and mortality and predicting the future NPC burden allows policymakers to make evidence-based [....] » Read More
Title : Cytotoxic activity of Salvia Officinalis in targeting JAK2/STAT3 pathway in breast cancer
Salma Alawadi Dawood , American university in Cairo (AUC), Egypt
Background: Breast cancer is the most common type of invasive cancer in women in their forties and fifties. Recent evidence suggests that JAK2/STAT3 signaling is constitutively active in breast cancer. Previous studies suggest that plant extracts, including Salvia Officinalis, ha [....] » Read More
Title : Role of natural antioxidants in cancer chemoprevention and chemotherapy
Dhanapal Sakthisekaran, University of Madras, India
Cancer chemoprevention is the use of natural or synthetic compounds for the inhibition, delay, or reversal of carcinogenesis. Chemotherapy is one of the most common treatments for cancer. It uses certain drugs to kill cancer cells or to stop them from growing and spreading to oth [....] » Read More
Title : Novel QRN substance effect of non small cell lung cancer cells
Abdulkadir Geylani Sahan, Suleymaniye Institute, Turkey
Introduction: Cancer is a scary name even though it is named after an innocent animal, even called a disease. It has sought the door to many different ideas working to experience many other theories and treatment alternatives as a disease. Despite the drugs that are still us [....] » Read More
Title : Analysis of adverse events of anaplastic lymphoma kinase inhibitors reported to FDA adverse event reporting system (FAERS)
Paiboon Jungsuwadee, Fairleigh Dickinson University, United States
Targeted cancer therapy often causes fewer adverse effects than traditional chemotherapy drugs. Thus, targeted therapeutic drugs have become mainstream of several hematologic and solid malignancies including non-small cell lung cancer (NSCLC). The first anaplastic lymphoma kinase [....] » Read More
Title : A minimal epitope peptide lipid nanoparticle vaccine for the E7 HPV oncoprotein
Tingting Ye, Zhejiang University, China
Cancer vaccines based on peptide antigens aim at activating T cells and mediate tumor- specific killing, leading to durable tumor regression and prolonged survival. However, the poor efficiency of unformulated peptide antigen at generating antigen-specific CD8+ T cells in vivo re [....] » Read More
Title : Diagnostic value of combining tumor and inflammatory biomarkers in detecting common cancers in Korea
Young Sun Kim, Seoul National University Hospital Healthcare System Gangnam Center, Korea, Republic of
Background: The ultimate goal of cancer screening is to diagnose invasive cancers early, while they are still curable. We aimed to validate the diagnostic value of blood-derived protein biomarkers that we developed for six common cancer in Korea. Methods: We have discovered 12 p [....] » Read More
Title : Explainable gastric cancer risk prediction: machine learning based models trained on data from regular health check-up programs of asymptomatic screening population
Ji Hyun Song, Seoul National University, Korea, Republic of
Backgroud: Since early diagnosis and treatment of gastric cancer increases the survival rate, regular gastric cancer screening is recommended for the high-risk group of gastric cancer. Objective risk stratification and assessment would be helpful to develop personalized stra [....] » Read More
Title : Cancer risk in the residents living near industrial waste incinerators in Korea
Yong Dae Kim, Chungbuk National University, Korea, Republic of
Three industrial waste incinerators (IWIs) were built in 1999, 2001, and 2010, within a 3 km radius of a town with a population of around 5000 in Korea. This study evaluated whether residents near these three IWIs had increased cancer incidence than those from other areas in Kore [....] » Read More
Title : Dual roles of TRAIL-TRAIL receptor signaling for low dose Decitabine-induced anti-tumor effects on glioblastoma (GBM) cells
Su Jung Park, Ajou University School of Medicine, Korea, Republic of
Low doses of DNA methylation inhibitors (DNMTi), such as DAC, exert durable antitumor effects. In this study, we demonstrated that low doses of DAC exert anti-tumor effects, at least in part, by inducing TRAIL and TRAIL receptors. DAC-induced TRAIL signal regulates specific immun [....] » Read More
Title : Characterization of the role of Salt-Inducible Kinase 2 in hepatocellular carcinoma metastasis
Yick Pang Ching , The University of Hong Kong, Hong Kong
Primary liver cancer is one of the most diagnosed cancer and leading cause of cancer death worldwide with hepatocellular carcinoma (HCC) contributing the majority of all cases. Advanced HCC has very poor prognosis due to frequent recurrence and metastasis. Salt-inducible Kinase 2 [....] » Read More