The prognosis of breast cancer remains unpredictable despite of frequent change in treatment protocol since last few decades. As we understand the heterogenous nature of the disease, complex tumor biology etc. the treatment protocols have changed. There is an unprecedented transf [....] » Read More
In this keynote lecture, exotic nanomagnetic materials (magnetic nanorings - MNRs) will be introduced as a very promising material for application in magnetic hyperthermia (MHT), an advanced cancer therapeutic modality. The chemical synthesis and the characterization of the [....] » Read More
Background: Large language models (LLMs) are increasingly used in oncology clinical workflows; however, real-world clinician adoption has outpaced formal institutional guidance and systematic safety validation. Existing evaluations often rely on aggregate performance metrics, whi [....] » Read More
Currently, the primary methods for detecting the ovarian cancer (OC) are transvaginal ultrasound (TVUS) and blood tests for the cancer antigen 125 (CA125) biomarker. However, these methods alone are not suitably sensitive or specific to identify the disease in its early, asymptom [....] » Read More
Current screening methods—radiological imaging, DNA-based tests, and pathological assessments—often fail to detect malignancies at early stages. Despite technological advances, gene-based diagnostics specifically designed for early cancer detection remain limited. To [....] » Read More
Background: Colorectal carcinoma (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. Emerging evidence suggests that vitamin D, beyond its classical role in bone metabolism, may influence carcinogenesis through its effects on cell proliferation [....] » Read More
Background: Breast cancer remains the most commonly diagnosed malignancy and a leading cause of cancer-related mortality among women worldwide. Despite advances in diagnosis and treatment, its global burden continues to rise, highlighting the need for modifiable prognostic factor [....] » Read More
Today, artificial intelligence (AI) is one of the hottest buzzwords in technology. It is at the center of the global technological revolution, envisaged to replace or enhance human capabilities in the coming times. With AI projected to be one of the major disrupting forces in the [....] » Read More
The cancer drugs(SBDD) generally blocks cell signaling but it also blocks disintegration of lunar gravity(705) and electronic time(27 or 27*0.0019 = 0.0513 or 513) that would not co-exists driving to protein synthesis until neutralization of 27 e.g. 609(AFP) + 291 = 900 where 609 [....] » Read More
Objectives: Inflammation is a hallmark of HPV-mediated cervical cancer; Matrix metalloproteinase [MMP]-2 and tissue inhibitor of metalloproteinase [TIMP]-2 are emerging as pivotal players in inflammation and carcinogenesis. My study aimed to evaluate the role of MMP-2 (-735C>T [....] » Read More
Chromatin bridges are strands of incompletely segregated DNA connecting the anaphase poles or daughter nuclei. Chromatin bridges can arise from incompletely replicated DNA, defective resolution of DNA catenates or dicentric chromosomes which are formed by chromosome fusions. If u [....] » Read More
Introduction: Patient information during therapies and follow-up needs to be constantly adapted for a flawless integration of complex oncologic therapy concepts into clinical routine. This is a key step for an optimal, individualized patient information and guidance and, ultimate [....] » Read More
Bladder cancer is one of the most common malignancies worldwide, and early diagnosis and regular follow-up are crucial for improving patient prognosis. Cystoscopy and tissue biopsy, the gold standards for diagnosing bladder cancer, are invasive and may result in complications. Ur [....] » Read More
Background Armed conflicts severely disrupt cancer care delivery, destroying infrastructure and limiting access to essential diagnostics and treatments. Evidence on service challenges, adaptations, and policy implications remains fragmented. Methods This scopin [....] » Read More
Selenium deficiency is associated with impaired immunity and leukemogenesis. Selenium compounds exhibit antiproliferative and proapoptotic effects in leukemic models, indicating therapeutic potential. However, no comprehensive review has assessed selenium’s impact on leukem [....] » Read More
Although malignant neoplasms of the esophagus remain a very common disease, their diagnosis might often come late. This issue combined with excessive weight loss due to dysphagia and the association with cardiopulmonary diseases resulting from excessive tobacco use, makes patient [....] » Read More
Even through the esophageal cancer has innumerable treatment options, its prognosis is still unsettled. Because esophagectomy is rarely curative, others therapies, such as chemorradiation emerging in advanced disease followed or not surgery. The salvage esophagectomy is an altern [....] » Read More
Will be Updated Soon...
Patient-derived organoids (PDOs) provide a unique opportunity to study cancer as an evolving, heterogeneous disease while retaining clinically relevant features of individual tumors. We are developing integrated organoid platforms spanning Barrett’s esophagus (BE), esophage [....] » Read More
Breast cancer is one of the last things that bring to mind the word beautiful. But what if there was something beautiful about breast cancer missing from the equation of diagnosis and treatment for all this time? What if there was a way to diagnose nascent tumors before they atta [....] » Read More
Chimeric antigen receptor T-cell therapy has shown significant clinical benefit, particularly in hematologic malignancies; however, conventional CAR-T platforms still face important limitations, including fixed antigen specificity, antigen escape, limited controllability, and saf [....] » Read More
Background: Lung cancer remains a major cause of cancer-related mortality worldwide. In Brazil, despite advances in tobacco-control policies, mortality patterns may vary according to sociodemographic and regional characteristics, highlighting important inequalities in the burden [....] » Read More
Background: Upper tract urothelial carcinoma (UTUC) is a distinct malignancy arising from the renal pelvis or ureter. Globally, UTUC represents 5–10% of urothelial carcinomas, but in Taiwan its incidence reaches up to 30%, the highest reported worldwide. This epidemiologica [....] » Read More
Early and accurate cancer detection remains one of the most pressing challenges in clinical oncology, and deep convolutional neural networks (CNNs) have shown strong promise in automating diagnosis from medical images. However, the diagnostic performance of CNN architectures such [....] » Read More
Despite recent advancements in research, cancer metastasis and recurrence continue to be the primary causes of treatment failure. In this context, tumor progression and treatment resistance are progressively inferred as consequences of complex dynamic crosstalk within the tumor m [....] » Read More
Chromatin bridges are strings of mis-segregated chromatin connecting the anaphase poles or daughter nuclei in mitotic cell division and can arise from incomplete DNA replication or decatenation, or from dicentric chromosomes generated by end-to-end chromosome fusions. Chromatin b [....] » Read More
Background: Continuity of cancer care is essential for safe and effective treatment. However, maintaining continuous oncology services can be particularly challenging in resource-limited and crisis-affected settings. In Gaza, oncology patients and healthcare professionals face m [....] » Read More
Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundreds of FDA approved medical products. While nanomedicine has been around for several decades, new technological advances are pushing its boundaries. For exa [....] » Read More
Background: Predicting pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer is essential for personalizing treatment. AI-assisted ultrasound has emerged as a promising non invasive approach, yet a systematic review specifically evaluating the di [....] » Read More
Multiple myeloma (MM) is a relatively frequent type of hematological malignancy that consists of proliferation of abnormal plasma cells in the bone marrow. MGUS and SMM are asymptomatic precursor conditions that can potentially transition to multiple myeloma. Previous reports ind [....] » Read More
Background or Introduction: Chemical carcinogens classified by the International Agency for Research on Cancer (IARC) as Group 1 very probably contribute to cancer occurrence in over 13.5 million people and death from cancer in over seven million people. In percent, chemical elem [....] » Read More
Melanoma has emerged as a paradigm for modern cancer therapy, demonstrating how molecularly targeted treatments and immunotherapy can transform outcomes in advanced malignancy. Despite these advances, therapeutic resistance, tumor heterogeneity, immune evasion, and disease recurr [....] » Read More
Background Diethylnitrosamine (DEN) induces hepatic injury and can promote hepatocarcinogenesis. Quercetin (QR) and low-dose gamma irradiation (LDR) have been explored as hepatoprotective and anticancer-modulating agents, but their combined effects in DEN-induced liver cancer ha [....] » Read More
Cancer and its treatments frequently result in physical, cognitive, psychosocial, and functional impairments that adversely affect participation, independence, and quality of life. Occupational Therapy (OT) plays a pivotal role across the continuum of cancer care, extending from [....] » Read More
The challenges posed by lung cancer are immense. It is one of the most serious diseases, health-wise, due to various factors affecting patient outcomes, such as demographic, environmental, behavioral, treatment-related, and clinical factors. With the increasing availability of mu [....] » Read More
Artificial intelligence is increasingly being introduced into healthcare to address the growing burden of repetitive clinical and operational activities. However, the key question is not whether artificial intelligence can replace clinical work, but which activities can be respon [....] » Read More
Background: The cancers of the upper aerodigestive tract and oral cancers in particular represent a major global public health problem, with particularly high mortality rates in low- and middle-income countries. These cancers rank 16th among malignant tumors and are the 15th le [....] » Read More
Title : Fusion genes detection enhances clinical outcome prediction of hepatocellular carcinoma through machine learning analyses
Jianhua Luo, University of Pittsburgh School of Medicine, United States
Hepatocellular carcinoma is one of the most lethal malignancies for humans. Assessing the clinical outcomes of HCC remains challenging. In this study, a panel of 20 fusion genes in 200 hepatocellular carcinoma (HCC) samples was analyzed to predict the recurrence and survival rate [....] » Read More
Title : A case of papillary ductal carcinoma in situ coexisting with mucinous carcinoma of micro-papillary structure of the breast: A pathologic consideration of tumour microenvironment
Shinya Tajima, National Hospital Organization Shizuoka Medical Centre, Japan
We would like to present a only case study: However, our important findings might lead to help the interpretations of “tumour microenvironment (TME)”. We herein presenting about 70-year-old female. She presented with a palpable mass in the upper inner quadrant of t [....] » Read More
Title : Personalized oncology via precision oncology strategy for cancer care team: Developing targeted cancer therapy & advancing personalized cancer care
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). The concept of PPM is becoming increasingly relevant for cancer treatment, moving from the ‘one-size-fits-all’ [....] » Read More
Title : Personalized and precision oncology as a unique avenue to have the healthcare model renewed to secure national biosafety: to get cancer treated or cured?
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). In this sense, Personalized & Precision Oncology (PPO) is an innovative approach to cancer management and is oriented t [....] » Read More
Title : Modeling a novel SMARTer design using an optimizing diagnostic: quantitative evaluation of improved patient outcome and sample size reduction, and implications for lower clinical trial costs and facilitating registration
Floyd Taub, aiGENE, Inc., United States
Modern oncology commonly requires sequential treatment; however, trials for approval typically do not include direct testing of sequences. Adaptive trials and Sequential Multiple Assignment Randomized Trial (SMART) trials are often of approved drugs and are large, slow, complex, [....] » Read More
Title : Exploring stem cell applications in cancer treatment: A systematic bibliometric evaluation
Ahora Chehri, Johann Wolfgang Goethe-Universität Frankfurt am Main (Universität Frankfurt am Main), Germany
Purpose of the study: This study aims to analyze global research trends and emerging themes in the application of stem cell biology for cancer therapy. The intent is to map the intellectual landscape and identify key areas of focus and collaboration from 2020 to 2024. Me [....] » Read More
Title : A case report of recurrent adult-type ovarian granulosa cell tumor in a 22-year-old female: Long-term efficacy of fuzulopari combined with apatinib
Jinhua Wang, Jiangsu Cancer Hospital, China
Adult-type ovarian Granulosa Cell Tumor (AGCT) is a rare low-grade malignant sex cord-stromal tumor, accounting for 2–5% of all ovarian malignancies, with 95% of cases occurring in middle-aged women aged 45–55 years. Cases in young patients ≤25 years old are extrem [....] » Read More
Title : Targeting hypoxia inducible factor (HIF) through synergetic actions of active molecules found in some functional foods, an effective cancer therapy
Paulraj S, Chennai Snake Park Trust, India
The origin, growth and spread of various cancers follow some common regulatory paths. Although hundreds of genes are involved in this process, most of these paths are initiated and controlled by one dominant and central factor, the Hypoxia Inducible Factor 1α (HIF-1α) [....] » Read More
Title : Addressing socioeconomic inequalities in breast cancer care: A national clinical pathway proposal for Mexico
Maria Isabel Sollozo Dupont, National Institute of Perinatology Isidro Espinosa de los Reyes, Mexico
Breast cancer is a major public health issue since it is the most common cause of death from malignant neoplasms in women over 25 around the world, especially in low-income countries where death rates are higher. In Mexico, preventative efforts are made harder by the fact that sc [....] » Read More
Title : Stress induced cancer and cancer induced stress outcomes on patient psychological personality
Ramalingam K, Mediclone Biotech Research Centre, India
This study aims to investigate the profound interplay between lifestyle, environmental factors, and the psychological burden of a cancer diagnosis. While medical advancements have improved survival rates, the diagnosis frequently triggers a severe "fear psychosis," char [....] » Read More
Title : Mechanistic study on the activation of primary motor cortex (M1) in inhibiting ovarian cancer through IGLUR-mediated reversal of CD8⁺ T cell exhaustion
Dongyao Zhang, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China
Objective: Ovarian cancer (OC) immunosuppression severely limits therapeutic efficacy. While peripheral neural tumor regulation is recognized, the central nervous system's (CNS) role in modulating the tumor immune microenvironment (TIME) remains unclear. We aimed to map the p [....] » Read More
Title : Evaluation of uProcess for detection of oncogene sequences in buffer and urine by qPCR following 3-minute capture and 5-minute purification procedure
Floyd Taub, aiGENE, Inc., United States
Cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA), found in blood and urine, have firmly established themselves as key analytes for the diagnosis of various cancers and for defining therapy. Primary sequence and epigenetic markers within cfDNA are key in screening and monit [....] » Read More
Title : Integrated medical care for cancer under siddha system of Indian medicine - a science based
Anbuganapathi G, Anbu Hospital, India
In the Indian context, the Siddha system of medicine (one of the oldest traditional systems, primarily from South India) is increasingly utilized as a powerful complementary and alternative medicine (CAM) for cancer. This is one of the approved medical systems under the Ministry [....] » Read More
Title : Thin-section CT prediction of visceral pleural invasion in part-solid lung adenocarcinomas ≤3 cm: relationship-specific imaging features of pleural-attached and pleural-tag nodules
Jing Sheng, Shanghai Pulmonary Hospital, Tongji University, China
Purpose: To determine whether CT predictors of visceral pleural invasion (VPI) differ by tumor–pleural relationship in part-solid lung adenocarcinoma and to develop interpretable models for pleural-attached and pleural-tag nodules. Methods: This retrospective study include [....] » Read More
Title : Ferroptosis-independent lysosomal membrane permeabilization and autophagic dysfunction induced by curcumin in H1299 lung cancer cells
Jian Hong Lin, Hualien Tzu Chi Hospital, Taiwan
Ferroptosis is an iron-dependent form of regulated cell death characterized by excessive lipid peroxidation and oxidative damage to cellular and organelle membranes. Because lysosomes are membrane-bound organelles that are particularly susceptible to oxidative injury, ferroptosis [....] » Read More
Title : Prolonged disease control with tepotinib and local radiotherapy in an 84-year-old woman with MET exon 14-skipping metastatic NSCLC
Moganapriya, Tan Tock Seng Hospital, Singapore
Will be Updated Soon...
Title : Prolonged survival across four lines of therapy in resistant/relapsed extensive-stage small cell lung cancer with rare pancreatic metastasis
Moganapriya, Tan Tock Seng Hospital, Singapore
Will be Updated Soon...