Current screening methods—radiological imaging, DNA-based tests, and pathological assessments—often fail to detect malignancies at early stages. Despite technological advances, gene-based diagnostics specifically designed for early cancer detection remain limited. To [....] » Read More
Chromatin bridges are strings of mis-segregated chromatin connecting the anaphase poles or daughter nuclei in mitotic cell division and can arise from incomplete DNA replication or decatenation, or from dicentric chromosomes generated by end-to-end chromosome fusions. Chromatin b [....] » Read More
Chromatin bridges are strands of incompletely segregated DNA connecting the anaphase poles or daughter nuclei. Chromatin bridges can arise from incompletely replicated DNA, defective resolution of DNA catenates or dicentric chromosomes which are formed by chromosome fusions. If u [....] » Read More
Selenium deficiency is associated with impaired immunity and leukemogenesis. Selenium compounds exhibit antiproliferative and proapoptotic effects in leukemic models, indicating therapeutic potential. However, no comprehensive review has assessed selenium’s impact on leukem [....] » Read More
Sexual health is a fundamental component of quality of life that is frequently compromised in cancer patients. In melanoma care, these issues remain under addressed despite increasing survivorship. This scoping review aimed to map the current literature on sexual health concerns [....] » Read More
The cancer drugs(SBDD) generally blocks cell signaling but it also blocks disintegration of lunar gravity(705) and electronic time(27 or 27*0.0019 = 0.0513 or 513) that would not co-exists driving to protein synthesis until neutralization of 27 e.g. 609(AFP) + 291 = 900 where 609 [....] » Read More
Objectives: Inflammation is a hallmark of HPV-mediated cervical cancer; Matrix metalloproteinase [MMP]-2 and tissue inhibitor of metalloproteinase [TIMP]-2 are emerging as pivotal players in inflammation and carcinogenesis. My study aimed to evaluate the role of MMP-2 (-735C>T [....] » Read More
Background: Upper tract urothelial carcinoma (UTUC) is a distinct malignancy arising from the renal pelvis or ureter. Globally, UTUC represents 5–10% of urothelial carcinomas, but in Taiwan its incidence reaches up to 30%, the highest reported worldwide. This epidemiologica [....] » Read More
Objective The artificial intelligence(AI)-assisted detection reduces underdiagnosed or overlooked early esophageal cancers. We performed a meta-analysis to determine the diagnostic accuracy of AI used in white light endoscopy of patients with early esophageal cancer. Methods A [....] » Read More
Sinonasal squamous cell carcinoma (SNSCC) is a rare head and neck malignancy that often presents at an advanced stage because initial symptoms mimic benign inflammatory disease. In high tuberculosis (TB) burden countries such as Indonesia, therapeutic decision-making may be furth [....] » Read More
Title : Will be Updated Soon..
Jose Manuel Cervera Grau, Preclinical Lab and Computational Drug Discovery Program, Relayer Biotech Inc, Spain
Will be Updated Soon...
Title : Will be Updated Soon..
Jianhua Luo, University of Pittsburgh School of Medicine, United States
Will be Updated Soon...
Title : A case of papillary ductal carcinoma in situ coexisting with mucinous carcinoma of micro papillary structure of the breast: A pathologic consideration
Shinya Tajima, National Hospital Organization Shizuoka Medical Centre, Japan
We would like to present a only case study: However, our important findings might lead to help the interpretations of “tumour microenvironment (TME)”. We herein presenting about 70-year-old female. She presented with a palpable mass in the upper inner quadrant of t [....] » Read More
Title : Personalized oncology via precision oncology strategy for cancer care team: Developing targeted cancer therapy & advancing personalized cancer care
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). The concept of PPM is becoming increasingly relevant for cancer treatment, moving from the ‘one-size-fits-all’ [....] » Read More
Title : Personalized and precision medicine as a unique avenue to have the healthcare model renewed to secure national biosafety: to get cancer treated or cured?
Sergey Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). In this sense, Personalized & Precision Oncology (PPO) is an innovative approach to cancer management and is oriented t [....] » Read More
Title : Addressing socioeconomic inequalities in breast cancer care: A national clinical pathway proposal for Mexico
Maria Isabel Sollozo Dupont, National Institute of Perinatology Isidro Espinosa de los Reyes, Mexico
Breast cancer is a major public health issue since it is the most common cause of death from malignant neoplasms in women over 25 around the world, especially in low-income countries where death rates are higher. In Mexico, preventative efforts are made harder by the fact that sc [....] » Read More
Title : Targeting hypoxia inducible factor (HIF) through synergetic actions of active molecules found in some functional foods, an effective cancer therapy
Paulraj S, Chennai Snake Park Trust, India
The origin, growth and spread of various cancers follow some common regulatory paths. Although hundreds of genes are involved in this process, most of these paths are initiated and controlled by one dominant and central factor, the Hypoxia Inducible Factor 1α (HIF-1α) [....] » Read More
Title : Whole genomic sequence for personalized treatments in radiation oncology
K R Muralidhar, Karkinos Healthcare Private Limited, India
Introduction and Objective: Radiation therapy plays a central role in cancer management; however, its success is often limited by tumour radio resistance and the risk of late treatment-related toxicities, even with advanced technologies and across various forms of radiation and i [....] » Read More
Title : Predicting immune checkpoint inhibitor cardiotoxicity using machine learning: A systematic review of model performance and methodological quality
Vaibhav Roy, Sharda University, India
Background: Immune checkpoint inhibitors (ICIs) significantly improve cancer outcomes but can cause rare, potentially fatal cardiotoxicity, including myocarditis and major adverse cardiovascular events (MACE). Machine learning (ML) and artificial intelligence (AI) models hav [....] » Read More
Title : Pomegranate peel extract sensitizes hepatocellular carcinoma cells to ionizing radiation, Induces apoptosis and inhibits MAPK, JAK/STAT3, β-Catenin/NOTCH and SOCS3 signaling
Nermeen Mohamed Elbakary, Egyptian Atomic Energy Authority, Egypt
Tumor resistance is typically blamed for the failure of radiotherapy and chemotherapy to treat cancer in clinic patients. To improve the cytotoxicity of tumor cells using radiation in conjunction with specific tumor-selective cytotoxic drugs is crucial. Pomegranate has received o [....] » Read More
Title : Diagnostic and therapeutic challenges: Plasmablastic lymphoma with myelomatous bone marrow involvement and neurological manifestations
Aiman Majid, Liaquat National Hospital, Pakistan
Plasmablastic lymphoma is considered as not only as rarest entity as well as one of the most aggressive subtype of diffuse large B-cell lymphoma, which is mostly associated with immunocompromised states, but some cases also reported in immunocompetent patients. As we have in our [....] » Read More
Title : Chemotherapy induced amenorrhea among premenopausal breast cancer patients, prevalence, associated factors and health related quality of life in tanzania.
Mariam Ally Uledi, Bugando Medical Centre, Tanzania, United Republic of
Background: Globally, there is an increase in breast cancer (BC) diagnoses before the age of 40 years were these individuals are in their reproductive age. One of the most significant side effects of chemotherapy for premenopausal women with BC is Chemotherapy-induced Amenorrhea [....] » Read More
Title : Implementation of a novel breast laparoscopic or robotic surgery curriculum
Yunjian, Sun Yat-Sen University First Affiliated Hospital, China
Background: Over the past decade, Robotic and laparoscopic techniques in nipple-sparing mastectomy (NSM), have gained prominence in the field of breast surgery. However, the complexity of these procedures necessitates systematic training programs to ensure surgical competency. Th [....] » Read More
Title : Survivorship and long term care in cancer
Mercy Osoro, National Cancer Institute of Kenya, Kenya
Background: With rising cancer incidence and expanding access to treatment, the population of cancer survivors is increasing. However, survivorship and long-term care remain fragmented, with many patients lacking structured follow-up, psychosocial support, and management of late [....] » Read More
Title : CES2-Armed oncolytic adenovirus: A multifunctional immunotherapeutic platform integrating oncolysis and immune modulation for enhanced cancer therapy
Abhishek Swarnakar, CSIR Indian Institute of Chemical Biology, India
Tumor-infiltrating lymphocytes (TILs) strongly influence clinical outcomes in many solid cancers, yet ovarian tumors frequently retain an immunologically “cold” phenotype that prevents effective immune entry and sustains immune evasion. Although oncolytic adenoviruses [....] » Read More